| Grant number: |
16/19712-9
|
| Support type: | Scholarships in Brazil - Post-Doctorate |
| Effective date (Start): |
November 01, 2016
|
| Effective date (End): |
September 30, 2020
|
| Field of knowledge: | Biological Sciences
-
Biophysics
-
Molecular Biophysics |
|
| Principal Investigator: | Glaucius Oliva |
| Grantee: | Andre Schutzer de Godoy |
|
| Home Institution: |
Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
|
|
| Associated research grant: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery,
AP.CEPID
|
|
|
Abstract
The Zika Fever, caused by the Zika Virus (ZIKV), is an emerging disease that in 2016 reached all five continents, achieving the status of a pandemic disease. It not only causes Dengue-like symptoms, the ZIKV can also affect the fetus developing during pregnancy, as well as cause neurological problems in adults, such as the Guillain-Barré Syndrome. Despite the global efforts so far, the mechanism of transmission, replication, immune evasion and also possible negative effects caused by the ZIKV are not fully understood. So far, there are no treatments or efficient ways of eradicating the virus, and prevention and control of the mosquito are the only way of fighting the ZIKV. The ZIKV is a positive chain retrovirus, where its genetic material translates a single poliprotein that is cleaved into ten different proteins. Of those, two form the viral envelope, one the capsid, and seven are involved in the virus replication. The proteins of the envelope and the NS1-ladder-domain, NS3-protease and NS5-methyltransferase have had parts of their tridimensional structures solved. Our proposal is to study the not yet solved proteins of ZIKV, by using biomolecular and X-ray crystallography techniques, aiming the structural determination of those. Once determined, the tridimensional structures will be used for the study of ligands with antiviral applicability. This project is part of the CEPID CIBFar from FAPESP, and has a secondary goal of establishing the necessary bases for the study of viruses in our lab. (AU)
|
|
Scientific publications
(5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PUHL, ANA C.;
BOGART, JONATHAN W.;
HABERMAN, VICTORIA A.;
LARSON, JACOB E.;
GODOY, ANDRE S.;
NORRIS-DROUIN, JACQUELINE L.;
CHOLENSKY, STEPHANIE H.;
LEISNER, TINA M.;
FRYE, V, STEPHEN;
PARISE, V, LESLIE;
BOWERS, ALBERT A.;
PEARCE, KENNETH H.
Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1.
ACS Chemical Biology,
v. 15,
n. 6,
p. 1505-1516,
JUN 19 2020.
Web of Science Citations: 0.
DE GODOY, ANDRE SCHUTZER;
FERNANDES, RAFAELA SACHETTO;
CAMPOS AGUIAR, ANNA CAROLINE;
BUENO, RENATA VIEIRA;
DE MORAES ROSO MESQUITA, NATHALYA CRISTINA;
CARVALHO GUIDO, RAFAEL VICTORIO;
OLIVA, GLAUCIUS.
Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases.
CURRENT OPINION IN STRUCTURAL BIOLOGY,
v. 59,
p. 65-72,
DEC 2019.
Web of Science Citations: 0.