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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems

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Author(s):
de Lima Nascimento, Tatiana Rita [1] ; de Amoedo Campos Velo, Marilia Mattar [2] ; Silva, Camila Felix [1] ; Silva Costa Cruz, Sara Brito [1] ; Cavalcanti Gondim, Brenna Louise [1, 3] ; Lia Mondelli, Rafael Francisco [2] ; Cancado Castellano, Lucio Roberto [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Paraiba, Tech Sch Hlth UFPB, Human Immunol Res & Educ Grp GEPIH, Joao Pessoa, Paraiba - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Operat Dent Endodont & Dent Mat, Sao Paulo, SP - Brazil
[3] State Univ Paraiba, Dept Dent, Postgrad Program Dent, Campina Grande, Paraiba - Brazil
Total Affiliations: 3
Document type: Review article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 25, n. 37, p. 3997-4012, 2019.
Web of Science Citations: 0
Abstract

Background: The high surface-to-volume ratio of polymeric nanofibers makes them an effective vehicle for the release of bioactive molecules and compounds such as growth factors, drugs, herbal extracts and gene sequences. Synthetic polymers are commonly used as sensors, reinforcements and energy storage, whereas natural polymers are more prone to mimicking an extracellular matrix. Natural polymers are a renewable resource and classified as an environmentally friendly material, which might be used in different techniques to produce nanofibers for biomedical applications such as tissue engineering, implantable medical devices, antimicrobial barriers and wound dressings, among others. This review sheds some light on the advantages of natural over synthetic polymeric materials for nanofiber production. Also, the most important techniques employed to produce natural nanofibers are presented. Moreover, some pieces of evidence regarding toxicology and cell-interactions using natural nanofibers are discussed. Clearly, the potential extrapolation of such laboratory results into human health application should be addressed cautiously. (AU)

FAPESP's process: 19/06045-2 - Synthesis and physical-chemical characterization of a cotton-wool-like nanofibers biopolymer of graphene oxide
Grantee:Rafael Francisco Lia Mondelli
Support Opportunities: Regular Research Grants