| Full text | |
| Author(s): Show less - |
Slavov, S. N.
[1, 2]
;
Maraninchi Silveira, R.
[2]
;
Hespanhol, M. R.
[2]
;
Sauvage, V.
[3]
;
Rodrigues, E. S.
[2]
;
Fontanari Krause, L.
[4]
;
Bittencourt, H. T.
[5]
;
Caro, V.
[6]
;
Laperche, S.
[3]
;
Covas, D. T.
[2]
;
Kashima, S.
[2]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14051140 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Reg Blood Ctr Ribeirao Preto, BR-14051140 Ribeirao Preto, SP - Brazil
[3] Ctr Natl Reference Risques Infect Transfus, INTS, Dept Etud Agents Transmissibles Sang DATS, F-75015 Paris - France
[4] Franciscan Univ, Lab Biosci, BR-97010030 Santa Maria, RS - Brazil
[5] Inst Hematol & Hemotherapy Amapa, BR-68900074 Macapa, Amapa - Brazil
[6] Inst Pasteur, Environm & Infect Risks Res & Expertise Unit, Lab Urgent Response Biol Threats, PGP, F-75724 Paris - France
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | TRANSFUSION CLINIQUE ET BIOLOGIQUE; v. 26, n. 4, p. 234-239, NOV 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Objectives. - The objectives of this study were to evaluate the prevalence of Human Pegivirus-1 (HPgV-1) viremia and genotype diversity among healthy blood donors from the Eastern Brazilian Amazon (city of Macapa, State of Amapa). There is little information for prevalence and circulation of HPgV-1 in this remote Brazilian region. Materials and methods. - We conducted a study evaluating the HPgV-1 RNA prevalence and circulating genotypes in 431 volunteer blood donors originating from the Eastern Brazilian Amazon. The obtained HPgV-1 positive samples were submitted to sequencing and genotyping analysis in order to examine the genotype diversity of this virus in the Brazilian Amazon. Results. - Our results demonstrated a prevalence of HPgV-1 RNA in 9.5% of the tested blood donors. The phylogenetic analyses of the detected positive samples showed the presence of HPgV-1 genotypes 1, 2 and 3. The most frequently detected genotype was 2 (78.0% of the cases) represented by sub-genotypes 2A (39.0%) and 2B (39.0%). At lower rates, genotypes 1 (14.6%) and 3 (7.4%) were also detected. Conclusion. - Our results revealed the presence of genotypes with European, Asiatic and African endemicity in Amazonian blood donors, probably due to the complex miscegenation processes that took place in this Brazilian region. More investigations, including information for the prevalence of HPgV-1 RNA in blood donors from other Latin American countries are needed to estimate the viremic rates and genotype distribution of this virus in a highly diverse continent like South America. (C) 2019 Societe francaise de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved. (AU) | |
| FAPESP's process: | 09/16623-1 - Molecular pathogenesis and clinical consequences of the infections caused by the Human Parvovirus B19 and Human Cytomegalovirus among patients with hemaglobinopathies and haemophilia |
| Grantee: | Svetoslav Nanev Slavov |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/23205-8 - Evaluation of the impact of emerging and reemerging viruses in the field of hemotherapy and stem cell transplantation by multiple-research approach |
| Grantee: | Svetoslav Nanev Slavov |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy |
| Grantee: | Dimas Tadeu Covas |
| Support Opportunities: | Research Projects - Thematic Grants |