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Evaluation of the impact of emerging and reemerging viruses in the field of hemotherapy and stem cell transplantation by multiple-research approach

Grant number: 17/23205-8
Support type:Research Grants - Young Investigators Grants
Duration: August 01, 2018 - July 31, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Svetoslav Nanev Slavov
Grantee:Svetoslav Nanev Slavov
Home Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
Assoc. researchers: Ana Cristina Silva Pinto ; Anna Maria Eis-Huebinger ; Belinda Pinto Simoes ; Caro Valerie ; Clarisse Martins Machado ; Dimas Tadeu Covas ; Gil Cunha de Santis ; Jose Mauro Kutner ; Mathias Vandenbogaert ; Nelson Hamerschlak ; Sanny Marcele da Costa Lira ; Sauvage ; Simone Kashima Haddad ; Syria Laperche
Associated scholarship(s):19/08528-0 - Application of bioinformatic procedures for identification of the impact of the viral infections in hemotherapy, BP.MS
19/07861-8 - Development of a bioinformatic pipeline for identification of emerging infectious diseases among patients in regimen of chronic transfusion, BP.MS
18/22009-3 - Activities of technical support in the collection of samples and molecular techniques in patients with sickle cell disease submitted to multiple transfusions, BP.TT
18/15826-5 - Evaluation of the impact of emerging and reemerging viruses in the field of hemotherapy and stem-cell transplantation by multiple-research approach, BP.JP


In the last decades, the scientific attention has been largely turned to a specific area of the clinical virology comprised by the emerging and reemerging viruses. This is due to the fact that these infectious agents have been recognized as a continuing threat to human health. Many of them can be transmitted by hemotherapy procedures including application of hemoderivatives or hematopoietic stem cell transplantations (HSCT). In the majority of cases, the emerging infections are represented by zoonotic viruses with exotic natural cycles, which are transmitted by insect vectors. Their dissemination in the human population can be related to high morbidity outbreaks with many asymptomatic infections which in turn can impact the hemotherapy process. In Brazil, there have been no comprehensive studies of such infections and their real threat for the hemotherapy processes is underestimated and largely unknown. This proposal, therefore, aims to investigate by multiple-based approaches including viral metagenomics next generation sequencing and state-of-the art molecular methods the significance of the emerging infections in the field of hemotherapy. For this purpose, the studies will be performed on plasma samples obtained from patients submitted to HSCT, multiply-transfused patients and deferred blood units. The project will also evaluate in a constant manner the prevalence of different viral infections in the blood donor population of our region which is subject to frequent arbovirus outbreaks. Therefore, the systematic approach of this project will add positive value for the understanding of the impact of the emerging viruses for the hemotherapy in Brazil and will capacitate Brazilian researches in the area of metagenomic analysis and next generation sequencing. This proposal represents a new research line in an already established scientific institution (Blood Center of Ribeirão Preto) and counts with national collaborations from important clinical institutions (Institute of Tropical Medicine, Hospital "Albert Einstein"-São Paulo, Faculty of Medicine of Ribeirão Preto-USP). Moreover, the project will be supported by many international collaborators from leading research clinical and bioinformatics centers from France and Germany (Pasteur Institute, National Institute of Blood Transfusion, Paris, France; Institute of Virology, University of Bonn, Germany), and aims at establishing a closely related research group for emerging viruses and hemotherapy/stem cell transplantation. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BEZERRA, RAFAEL DOS SANTOS; DIEFENBACH, CRISTIANE FRACAO; PEREIRA, DALNEI VEIGA; KASHIMA, SIMONE; SLAVOV, SVETOSLAV NANEV. Viral metagenomics performed in patients with acute febrile syndrome during Toxoplasma gondii outbreak in south Brazil. Brazilian Journal of Infectious Diseases, v. 24, n. 3, p. 250-255, MAY-JUN 2020. Web of Science Citations: 0.
SLAVOV, SVETOSLAV NANEV; GUARAGNA MACHADO, RAFAEL RAHAL; FERREIRA, ALEXANDER RODRIGO; SOARES, CAMILA PEREIRA; ARAUJO, DANIELLE BASTOS; LEAL OLIVEIRA, DANIELLE BRUNA; COVAS, DIMAS TADEU; DURIGON, EDISON LUIZ; KASHIMA, SIMONE. Zika virus seroprevalence in blood donors from the Northeastern region of Sao Paulo State, Brazil, between 2015 and 2017. Journal of Infection, v. 80, n. 1, p. 111-115, JAN 2020. Web of Science Citations: 0.
SLAVOV, S. N.; MARANINCHI SILVEIRA, R.; HESPANHOL, M. R.; SAUVAGE, V.; RODRIGUES, E. S.; FONTANARI KRAUSE, L.; BITTENCOURT, H. T.; CARO, V.; LAPERCHE, S.; COVAS, D. T.; KASHIMA, S. Human pegivirus-1 (HPgV-1) RNA prevalence and genotypes in volunteer blood donors from the Brazilian Amazon. TRANSFUSION CLINIQUE ET BIOLOGIQUE, v. 26, n. 4, p. 234-239, NOV 2019. Web of Science Citations: 0.
SLAVOV, S. N.; CHRISTOVA, I. S.; FERREIRA, A. R.; RODRIGUES, E. S.; BIANQUINI, M. L.; HESPANHOL, M. R.; COVAS, D. T.; KASHIMA, S. Serological evidence of Borrelia circulation among blood donors in the Sao Paulo state, Brazil. Transfusion Medicine, v. 29, n. 5, p. 358-363, OCT 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV N.; MACONETTO, JULIANA D. M.; MARTINEZ, EDSON Z.; SILVA-PINTO, ANA CRISTINA; COVAS, DIMAS T.; EIS-HUEBINGER, ANNA MARIA; KASHIMA, SIMONE. Prevalence of hepatitis E virus infection in multiple transfused Brazilian patients with thalassemia and sickle cell disease. Journal of Medical Virology, v. 91, n. 9, p. 1693-1697, SEP 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV N.; RODRIGUES, EVANDRA S.; SAUVAGE, VIRGINIE; CARO, VALERIE; DIEFENBACH, CRISTIANE F.; ZIMMERMANN, ANA M.; COVAS, DIMAS T.; LAPERCHE, SYRIA; KASHIMA, SIMONE. Parvovirus B19 seroprevalence, viral load, and genotype characterization in volunteer blood donors from southern Brazil. Journal of Medical Virology, v. 91, n. 7, p. 1224-1231, JUL 2019. Web of Science Citations: 0.
SLAVOV, SVETOSLAV NANEV; SILVEIRA, ROBERTA MARANINCHI; RODRIGUES, EVANDRA STRAZZA; DIEFENBACH, CRISTIANE FRACAO; ZIMMERMANN, ANA MARIA; COVAS, DIMAS TADEU; KASHIMA, SIMONE. Human pegivirus-1 pegivirus-1 (HPgV-1, GBV-C) RNA prevalence and genotype diversity among volunteer blood donors from an intra-hospital hemotherapy service in Southern Brazil. TRANSFUSION AND APHERESIS SCIENCE, v. 58, n. 2, p. 174-178, APR 2019. Web of Science Citations: 2.

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