| Full text | |
| Author(s): |
Fonseca, G. W. P. D.
[1]
;
dos Santos, Marcelo Rodrigues
[1]
;
de Souza, Francis Ribeiro
[1]
;
Takayama, Liliam
[2]
;
Rodrigues Pereira, Rosa Maria
[2]
;
Negrao, Carlos Eduardo
[3, 1]
;
Nunes Alves, Maria-Janieire de Nazare
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch, Heart Inst InCor, Av Dr Eneas de Carvalho Aguiar, 44 Cerqueira Cesar, BR-05403904 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Med Sch, Rheumatol Div, Bone Metab Lab, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ESC HEART FAILURE; v. 7, n. 1 DEC 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Aims The definition of sarcopenia based on appendicular lean mass/height ((2)) (ALM/height ((2))) is often used, although it can underestimate the prevalence of sarcopenia in overweight/obese patients with heart failure. Therefore, new methods have been proposed to overcome this limitation. We aimed to evaluate the prevalence of sarcopenia by three methods and compare body composition in this population. Methods and results We enrolled 168 male patients with heart failure (left ventricular ejection fraction <40%). Sixty-six patients (39.3%) were identified with sarcopenia by at least one method. The lower 20th percentile defined as the cut-off point for sarcopenia was 7.03 kg/m(2), -2.32 and 0.76 for Baumgartner's (20.8%), Newman's (21.4%), and Studenski's methods (21.4%), respectively. Patients with body mass index (BMI) <25 kg/m(2) were more likely to be identified by Baumgartner's than Studenski's method (P < 0.001). However, in patients with BMI >= 25 kg/m(2), Studenski's and Newman's methods were more likely to detect sarcopenia than Baumgartner's method (both P < 0.005). Patients were further divided into three subgroups: (i) patients classified in all indexes (n = 8), (ii) patients classified in Baumgartner's (sarcopenic; n = 27), and (iii) patients classified in both Newman's and Studenski's methods (sarcopenic obesity; n = 31). Comparing body composition among groups, all sarcopenic groups presented lower total lean mass compared with non-sarcopenic patients, whereas sarcopenic obese patients had higher total lean mass than lean sarcopenic patients. Conclusions Our results demonstrate that the prevalence of sarcopenia in overweight/obese patients is similar to lean sarcopenic patients when other methods are considered. In patients with higher BMI, Studenski's method seems to be more feasible to detect sarcopenia. (AU) | |
| FAPESP's process: | 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment |
| Grantee: | Carlos Eduardo Negrão |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/24306-0 - The effect of NEPRIlysin (LCZ696) on EXercise TOLerance, muscle vasodilatation, muscle strength and body composition in patients with Heart Failure - NEPRIExTol-HF Trial |
| Grantee: | Marcelo Rodrigues dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |