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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D

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Author(s):
Brito, Gilmar A. [1] ; Jung, Woo-Ok [1] ; Yoo, Minjin [1] ; Krische, Michael J. [1]
Total Authors: 4
Affiliation:
[1] Univ Texas Austin, Dept Chem, 105 & 24th St, A5300, Austin, TX 78712 - USA
Total Affiliations: 1
Document type: Journal article
Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION; v. 58, n. 52 NOV 2019.
Web of Science Citations: 4
Abstract

Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required. (AU)

FAPESP's process: 17/00734-5 - Catalytic synthesis of Type II polyketides via Hydrogen-Mediated C-C bond formation
Grantee:Gilmar Araujo Brito Junior
Support type: Scholarships abroad - Research Internship - Post-doctor