|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||March 01, 2010|
|Effective date (End):||September 30, 2013|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Organic Chemistry|
|Principal Investigator:||Leandro Helgueira de Andrade|
|Grantee:||Joel Savi dos Reis|
|Home Institution:||Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
Our work will be focused on the application of enoate reductases in the synthesis of chiral organoboron compounds, by an enantioselective reduction of vinyl organoboranes. After that, our efforts will be dedicated to the application of lipases as catalysts in the resolution of aminoboronic compounds. The kinetic resolution will be performed by an enantioselective acylation. Furthermore, we'll evaluate the dynamic kinetic resolution, which use a lipase as resolution agent, and metals, such as palladium or ruthenium as racemization agent. Besides, we intend to employ of transaminases as resolution catalysts. At this last stage, the kinetic resolution of aminoboronic substrates will be carry out by enantioselective oxidation catalyzed by transaminases. The transaminases also will be also employed as catalysts of reductive amination of ketones containing a boronic group.