Diet-induced maternal obesity alters insulin signalling in male mice offspring rec...
| Full text | |
| Author(s): |
e-Lacerda, Rodrigo Rodrigues
[1]
;
Teixeira, Caio Jordao
[1]
;
Bordin, Silvana
[2]
;
Antunes, Edson
[1]
;
Anhe, Gabriel Forato
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, BR-13083881 Campinas, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NUTRIENTS; v. 11, n. 12 DEC 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
It was previously demonstrated that non-allergen-sensitized rodents born to mothers exposed to a high-fat diet (HFD) spontaneously develop lower respiratory compliance and higher respiratory resistance. In the present study, we sought to determine if mice born to mothers consuming HFD would exhibit changes in inflammatory response and lung remodeling when subjected to ovalbumin (OVA) sensitization/challenge in adult life. Mice born to dams consuming either HFD or standard chow had increased bronchoalveolar lavage (BAL) levels of IL-1 beta, IL-4, IL-5, IL-10, IL-13, TNF-alpha and TGF-beta 1 after challenge with OVA. IL-4, IL-13, TNF-alpha and TGF-beta 1 levels were further increased in the offspring of HFD-fed mothers. Mice born to obese dams also had exacerbated values of leukocyte infiltration in lung parenchyma, eosinophil and neutrophil counts in BAL, mucus overproduction and collagen deposition. The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. Altogether, the present data support the unprecedented notion that the progeny of obese mice display exacerbated responses to sensitization/challenge with OVA, leading to the intensification of the morphological changes of lung remodeling. Such changes are likely to result from long-lasting changes in miR-155 and miR-133b expression. (AU) | |
| FAPESP's process: | 16/22722-6 - Influence of sexual gender on allergic lung inflammation in normolipidic and hyperlipidic mice exposed to ovalbumin |
| Grantee: | Rodrigo Rodrigues e Lacerda |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/20742-2 - Effects of PPAR-gamma or PPAR-alpha agonists on the metabolic programming induced by maternal caloric restriction during pregnancy and lactation |
| Grantee: | Gabriel Forato Anhê |
| Support type: | Regular Research Grants |
| FAPESP's process: | 17/15175-1 - Modulation of soluble guanylate cyclase and the intracellular levels of cyclic nucleotides in the lower urinary tract and prostate |
| Grantee: | Edson Antunes |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07607-8 - OCRC - Obesity and Comorbidities Research Center |
| Grantee: | Licio Augusto Velloso |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 15/18997-7 - Evaluation of the allergic response in the offspring born to and breastfed by obese and lean mice exposed to ovalbumin |
| Grantee: | Rodrigo Rodrigues e Lacerda |
| Support type: | Scholarships in Brazil - Doctorate |