Vitamin B2 and Folate Concentrations are Associated with ARA, EPA and DHA Fatty Acids in Red Blood Cells of Brazilian Children and Adolescents

Author(s):Show less -

Ued, Fabio V. ^{[1, 2]} ; Mathias, Mariana G. ^[1] ; Toffano, Roseli B. D. ^[1] ; Barros, Tamiris T. ^[1] ; Almada, Maria Olimpia R. V. ^[1] ; Salomao, Roberta G. ^[1] ; Coelho-Landell, Carolina A. ^[1] ; Hillesheim, Elaine ^[1] ; Camarneiro, Joyce M. ^[1] ; Camelo-Junior, Jose Simon ^[1] ; Aragon, Davi C. ^[1] ; Moco, Sofia ^[3] ; Kussmann, Martin ^{[3, 4]} ; Kaput, Jim ^{[3, 5]} ; Monteiro, Jacqueline P. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Bandeirantes Ave 3900, BR-14049900 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Bandeirantes Ave 3900, BR-14049900 Ribeirao Preto - Brazil

^[3] Ecole Polytech Fed Lausanne, Nestle Inst Hlth Sci, Innovat Sq, CH-1015 Lausanne - Switzerland

^[4] Frontiers, CH-1005 Lausanne - Switzerland

^[5] Vydiant, Gold River, CA 95816 - USA

• Document type: Journal article
• Source: NUTRIENTS; v. 11, n. 12 DEC 2019.
• Web of Science Citations: 0

Abstract

Vitamins B2, B6, B12, and folate are essential for methylation reactions and possibly influence the transport of polyunsaturated fatty acids in plasma and red blood cells (RBC). Associations between B-vitamin biomarkers and fatty acid (FA) profile were analyzed in Brazilian children and adolescents. This cross-sectional study included 249 children and adolescents, aged 9-13 years old. Dietary intake was assessed by the food frequency questionnaire and the healthy eating index (HEI). Biomarkers for vitamins B2, B6, B12, and folate were measured in plasma. The FA profile and the metabolites of one-carbon metabolism were measured in RBC. Associations were tested with multiple linear regression models. An increase of 1 nmol/L in vitamin B2 was associated with an increase of 0.19 mg/dL of EPA, 0.20 mg/dL of ARA, and 0.25 mg/dL of DHA in RBC. An increase of 1 ng/mL in plasma folate was associated with an increase of 0.14 mg/dL of EPA, 0.22 mg/dL of ARA, and 0.21 mg/dL of DHA in RBC. These findings highlight the importance of an adequate intake of vitamin B2 and folate in childhood, since they may improve the FA profile in RBCs and may help prevent cardiovascular disease. (AU)

• FAPESP's process: 12/20421-8 - A new strategy to analyze gene-nutrient interaction in children and adolescents
• Grantee: Jacqueline Pontes Monteiro
• Support Opportunities: Regular Research Grants