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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bran of cassava starch flour and bran of cassava flour as potential tablet excipients

Full text
Author(s):
Orsi, Valeria C. [1] ; Vila, Marta M. D. C. [1] ; Hanai-Yoshida, Valquiria M. [1] ; Chaud, V, Marco ; Balcao, Victor M. [2, 3, 1] ; Oliveira Jr, Jose M.
Total Authors: 6
Affiliation:
[1] Univ Sorocaba, PhageLab Lab Biofilms & Bacteriophages, BR-18023000 Sorocaba, SP - Brazil
[2] Univ Aveiro, Dept Biol, Campus Univ Santiago, P-3810193 Aveiro - Portugal
[3] Univ Aveiro, CESAM, Campus Univ Santiago, P-3810193 Aveiro - Portugal
Total Affiliations: 3
Document type: Journal article
Source: ARS PHARMACEUTICA; v. 60, n. 4, p. 205-211, 2019.
Web of Science Citations: 0
Abstract

Objectives: The physicochemical characteristics of bran of cassava starch flour and bran of cassava flour (viz. organoleptic characteristics, pH value, moisture content, total ashes, lipid, protein, starch and fiber contents) and biopharmacotechnical parameters (viz. granulometry, flow capacity, angle at rest, outflow time and apparent density) were evaluated aiming at assessing their potential use as tablet excipients. Methodos: Three tablet formulations of venlafaxine hydrochloride were proposed, having as excipients bran of cassava flour, bran of cassava starch flour and Starch 1500 (R). The tablets were produced using two different pressures (98 +/- 5 MPa and 32 +/- 6 Mpa) and their mechanical (hardness and friability) and dissolubility characteristics were evaluated. Results and Conclusions: The tablets produced with both cassava flours, using higher pressures, presented similar physicochemical characteristics to those obtained with the excipient Starch 1500 (R), thus indicating that cassava flours possess the potential to be used as disintegrating agents in tablets. (AU)

FAPESP's process: 18/05522-9 - PsaPhageKill - isolation, characterisation and use of lytic bacteriophages against Pseudomonas syringae PV. actinidiae to fight the cancer of kiwifruit: an efficient and ecofriendly alternative
Grantee:Vitor Manuel Cardoso Figueiredo Balcão
Support Opportunities: Scholarships abroad - Research