Freitas, Gileade P.
Lopes, Helena B.
Souza, Alann T. P.
Oliveira, Paula G. F. P.
Almeida, Adriana L. G.
Coelho, Paulo G.
Ferreira, Fernanda U.
Covas, Dimas T.
Beloti, Marcio M.
Rosa, Adalberto L.
Total Authors: 10
 Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Sao Paulo, SP - Brazil
 NYU, Sch Med, Hansjorg Wyss Dept Plast Surg, New York, NY 10016 - USA
 NYU, Coll Dent, Dept Biomat, New York, NY 10010 - USA
 Univ Sao Paulo, Sch Med Ribeirao Preto, Reg Blood Ctr Ribeirao Preto, Ctr Cell Based Res, Sao Paulo, SP - Brazil
 Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Clin Med, Sao Paulo, SP - Brazil
 Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Basic & Oral Biol, Sao Paulo, SP - Brazil
Total Affiliations: 6
Web of Science Citations:
Aim: The aim of this study was to investigate the effect of local injection of osteoblasts differentiated from bone marrow (BM-OB) or adipose tissue (AT-OB) mesenchymal stromal cells on bone tissue formation. Materials \& methods: Defects were created in rat calvaria and injected with BM-OB or AT-OB and phosphate-buffered saline without cells were injected as control. Bone formation was evaluated 4 weeks postinjection. Results: Injection of BM-OB or AT-OB resulted in higher bone formation than that obtained with control. The bone tissue induced by cell injections exhibited similar mechanical properties as those of pristine calvarial bone, and its molecular cues suggested the occurrence of a remodeling process. Conclusion: Results of this study demonstrated that cell therapy with osteoblasts induced significant bone formation that exhibited the same quality as that of pre-existent bone. (AU)