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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of cell therapy with osteoblasts differentiated from bone marrow or adipose tissue stromal cells on bone repair

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Author(s):
Freitas, Gileade P. [1] ; Lopes, Helena B. [1] ; Souza, Alann T. P. [1] ; Oliveira, Paula G. F. P. [1] ; Almeida, Adriana L. G. [1] ; Coelho, Paulo G. [2, 3] ; Ferreira, Fernanda U. [4] ; Covas, Dimas T. [5, 4] ; Beloti, Marcio M. [6] ; Rosa, Adalberto L. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Sao Paulo, SP - Brazil
[2] NYU, Sch Med, Hansjorg Wyss Dept Plast Surg, New York, NY 10016 - USA
[3] NYU, Coll Dent, Dept Biomat, New York, NY 10010 - USA
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Reg Blood Ctr Ribeirao Preto, Ctr Cell Based Res, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Clin Med, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Basic & Oral Biol, Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: REGENERATIVE MEDICINE; v. 14, n. 12, p. 1107-1119, DEC 2019.
Web of Science Citations: 0
Abstract

Aim: The aim of this study was to investigate the effect of local injection of osteoblasts differentiated from bone marrow (BM-OB) or adipose tissue (AT-OB) mesenchymal stromal cells on bone tissue formation. Materials \& methods: Defects were created in rat calvaria and injected with BM-OB or AT-OB and phosphate-buffered saline without cells were injected as control. Bone formation was evaluated 4 weeks postinjection. Results: Injection of BM-OB or AT-OB resulted in higher bone formation than that obtained with control. The bone tissue induced by cell injections exhibited similar mechanical properties as those of pristine calvarial bone, and its molecular cues suggested the occurrence of a remodeling process. Conclusion: Results of this study demonstrated that cell therapy with osteoblasts induced significant bone formation that exhibited the same quality as that of pre-existent bone. (AU)

FAPESP's process: 14/26864-4 - Effect of Local Injections of Mesenchymal Stem Cells and Osteoblasts on Bone Regeneration
Grantee:Gileade Pereira Freitas
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/21439-6 - Mesenchymal stem cells and osteoblasts: evaluation of molecular signatures and their potential for bone regeneration
Grantee:Adalberto Luiz Rosa
Support type: Regular Research Grants
FAPESP's process: 09/54142-5 - Creation of a Multi-User Laboratory for the analysis of three-dimensional images of biological tissues and biomaterials (3D BIOLAB)
Grantee:Adalberto Luiz Rosa
Support type: Multi-user Equipment Program