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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hydrogen sulfide and dermatological diseases

Full text
Author(s):
Coavoy-Sanchez, Silvia A. [1] ; Costa, Soraia K. P. [1] ; Muscara, Marcelo N. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Ave Prof Lineu Prestes 1524, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: British Journal of Pharmacology; v. 177, n. 4, SI, p. 857-865, FEB 2020.
Web of Science Citations: 2
Abstract

Skin diseases constitute a major health problem affecting a high proportion of the population every day and have different aetiologies that include inflammation, infections, and tumours. Hydrogen sulfide (H2S) is a gaseous signalling molecule recognized as a gasotransmitter together with NO and carbon monoxide. Under physiological conditions, H2S is produced in the skin by enzymic pathways and plays a physiological role in a variety of functions, such as vasodilatation, cell proliferation, apoptosis, and inflammation. Alterations of H2S production are implicated in a variety of dermatological diseases, such as psoriasis, melanoma, and other dermatoses. On the other hand, H2S-releasing-based therapies based on H2S donor compounds are being developed to treat some of these situations. In this review, we provide an up-to-date overview of the role of H2S in the normal skin and its clinical and pathological significance, as well as the therapeutic potential of different H2S donors for treatment of skin diseases. Linked Articles This article is part of a themed section on Hydrogen Sulfide in Biology \& Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc (AU)

FAPESP's process: 17/16409-6 - Effect of hydrogen sulfide (H2S) donors on experimental atopic dermatitis in mice.
Grantee:Silvia Abigail Coavoy Sanchez
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/24518-1 - Role of hydrogen sulfide (H2S) in the inflammatory and nociceptive responses induced by carrageenan in the rat temporomandibular joint
Grantee:Marcelo Nicolas Muscara
Support Opportunities: Regular Research Grants
FAPESP's process: 16/06146-5 - Bioavailability of Hydrogen Sulfide in a topical nanoformulation in experimental psoriasis
Grantee:Soraia Katia Pereira Costa
Support Opportunities: Regular Research Grants