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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

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Author(s):
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Alice Corrêa Silva-Sousa [1] ; Jardel Francisco Mazzi-Chaves [2] ; Jessica Vavassori Freitas [3] ; Alessandro Guimarães Salles [4] ; Raquel Assed Bezerra da Silva Segato [5] ; Léa Assed Bezerra da Silva [6] ; Lívia Azeredo Alves Antunes [7] ; Leonardo Santos Antunes [8] ; Flares Baratto-Filho [9] ; Manoel Damião Sousa-Neto [10] ; Erika Calvano Küchler
Total Authors: 11
Affiliation:
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[1] Universidade de Ribeirão Preto. School of Dentistry - Brasil
[2] Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[3] Universidade Positivo. School of Health Sciences. Graduate Program in Dentistry - Brasil
[4] Universidade Federal Fluminense. School of Dentistry of Nova Friburgo. Department of Specific Formation - Brasil
[5] Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil
[6] Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil
[7] Universidade Federal Fluminense. School of Dentistry of Nova Friburgo. Department of Specific Formation - Brasil
[8] Universidade Federal Fluminense. School of Dentistry of Nova Friburgo. Department of Specific Formation - Brasil
[9] Universidade Positivo. School of Health Sciences. Graduate Program in Dentistry - Brasil
[10] Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
Total Affiliations: 11
Document type: Journal article
Source: Brazilian Dental Journal; v. 31, n. 1, p. 19-24, 2020-03-06.
Abstract

Abstract This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP. (AU)

FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants