| Full text | |
| Author(s): |
Boldrini, Vinicius O.
[1, 2, 3]
;
Brandao, Carlos Otavio
[4, 1, 3]
;
Pimentel, V, Maria Lucia
;
Vidal, Aline
[3]
;
Mansur, Leticia F.
[5]
;
Quintiliano, Raphael P. S.
[3]
;
Santos, Leonilda M. B.
[1, 2, 3]
;
Farias, Alessandro S.
[1, 2, 3, 6]
Total Authors: 8
|
| Affiliation: | [1] Natl Inst Sci & Technol Neuroimmunomodulat INCT N, Rio De Janeiro - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab, Campinas - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Neuroimmunol Unit, Campinas - Brazil
[4] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil
[5] Pimentel, Maria Lucia, V, Santa Casa de Misericordia Rio de Janeiro, Rio De Janeiro - Brazil
[6] Div Immune Mediated Dis, Expt Med Res Cluster, Campinas - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Journal of Neuroimmunology; v. 340, MAR 15 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds. (AU) | |
| FAPESP's process: | 17/21363-5 - Regulation of JAK/STAT/SOCS in the ontogen of IFNg-producing cells derivated from encephalitogenic Th17 cells during the clinical evolution of experimental autoimmune encephalomyelitis |
| Grantee: | Alessandro dos Santos Farias |
| Support type: | Regular Research Grants |
| FAPESP's process: | 15/22052-8 - Role of Runx3 in the regulatory mechanism of effector profile of TCD4+ encephalitogenic lymphocytes in experimental autoimmune encephalomyelitis |
| Grantee: | Alessandro dos Santos Farias |
| Support type: | Regular Research Grants |
| FAPESP's process: | 12/01408-0 - Study of migratory, effector and regulatory pattern of autoreactive T lymphocytes, previously transduced with GFP in experimental demyelinating diseases |
| Grantee: | Alessandro dos Santos Farias |
| Support type: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 19/06372-3 - Multiparametric flow cytometry |
| Grantee: | Alessandro dos Santos Farias |
| Support type: | Multi-user Equipment Program |