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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder

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Author(s):
Boldrini, Vinicius O. [1, 2, 3] ; Brandao, Carlos Otavio [4, 1, 3] ; Pimentel, V, Maria Lucia ; Vidal, Aline [3] ; Mansur, Leticia F. [5] ; Quintiliano, Raphael P. S. [3] ; Santos, Leonilda M. B. [1, 2, 3] ; Farias, Alessandro S. [1, 2, 3, 6]
Total Authors: 8
Affiliation:
[1] Natl Inst Sci & Technol Neuroimmunomodulat INCT N, Rio De Janeiro - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab, Campinas - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Neuroimmunol Unit, Campinas - Brazil
[4] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil
[5] Pimentel, Maria Lucia, V, Santa Casa de Misericordia Rio de Janeiro, Rio De Janeiro - Brazil
[6] Div Immune Mediated Dis, Expt Med Res Cluster, Campinas - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Journal of Neuroimmunology; v. 340, MAR 15 2020.
Web of Science Citations: 0
Abstract

Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds. (AU)

FAPESP's process: 17/21363-5 - Regulation of JAK/STAT/SOCS in the ontogen of IFNg-producing cells derivated from encephalitogenic Th17 cells during the clinical evolution of experimental autoimmune encephalomyelitis
Grantee:Alessandro dos Santos Farias
Support type: Regular Research Grants
FAPESP's process: 15/22052-8 - Role of Runx3 in the regulatory mechanism of effector profile of TCD4+ encephalitogenic lymphocytes in experimental autoimmune encephalomyelitis
Grantee:Alessandro dos Santos Farias
Support type: Regular Research Grants
FAPESP's process: 12/01408-0 - Study of migratory, effector and regulatory pattern of autoreactive T lymphocytes, previously transduced with GFP in experimental demyelinating diseases
Grantee:Alessandro dos Santos Farias
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 19/06372-3 - Multiparametric flow cytometry
Grantee:Alessandro dos Santos Farias
Support type: Multi-user Equipment Program