| Full text | |
| Author(s): |
Prior, Kimberley F.
[1, 2]
;
Rijo-Ferreira, Filipa
[3, 4]
;
Assis, Patricia A.
[5]
;
Hirako, Isabella C.
[5, 6]
;
Weaver, David R.
[7, 8]
;
Gazzinelli, Ricardo T.
[5, 6]
;
Reece, Sarah E.
[1, 2]
Total Authors: 7
|
| Affiliation: | [1] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian - Scotland
[2] Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Midlothian - Scotland
[3] Univ Texas Southwestern Med Ctr Dallas, Peter ODonnell Jr Brain Inst, Dept Neurosci, Dallas, TX 75390 - USA
[4] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX - USA
[5] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA - USA
[6] Fundacao Oswaldo Cruz Minas, Lab Imunopatol, Belo Horizonte, MG - Brazil
[7] Univ Massachusetts, Med Sch, Dept Neurobiol, Worcester, MA - USA
[8] Univ Massachusetts, Med Sch, NeuroNexus Inst, Worcester, MA - USA
Total Affiliations: 8
|
| Document type: | Review article |
| Source: | CELL HOST & MICROBE; v. 27, n. 2, p. 176-187, FEB 12 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Biological rhythms appear to be an elegant solu.ion to the challenge of coordinating activities with the consequences of the Earth's daily and seasonal rotation. The genes and molecular mechanisms underpinning circadian clocks in multicellular organisms are well understood. In contrast, the regulatory mechanisms and fitness consequences of biological rhythms exhibited by parasites remain mysterious. Here, we explore how periodicity in parasite traits is generated and why daily rhythms matter for parasite fitness. We focus on malaria (Plasmodium) parasites which exhibit developmental rhythms during replication in the mammalian host's blood and in transmission to vectors. Rhythmic in-host parasite replication is responsible for elicit' g inflammatory responses, the severity of disease symptoms, and fueling transmission, as well as conferring tolerance to anti-parasite drugs. Thus, understanding both how and why the timing and synchrony of parasites are connected to the daily rhythms of hosts and vectors may make treatment more effective and less toxic to hosts. (AU) | |
| FAPESP's process: | 16/23618-8 - Immunological mechanisms of resistance and disease in malaria |
| Grantee: | João Santana da Silva |
| Support Opportunities: | Research Projects - Thematic Grants |