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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns

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Author(s):
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Vedovello, Danila [1] ; Witkin, Steven S. [2, 3] ; Botelho Silva, Andrea Cristina [1] ; Gillo Fajardo, Thamirys Cosmo [1] ; Mello, Alexandra Siqueira [1] ; Antunes Pascalicchio Bertozzi, Ana Paula [1, 2] ; da Silva, Alify Bertoldo [2] ; Vieira Filho, Nemesio Florence [2] ; Duarte Rodrigues, Maria Manoela [2] ; Gazeta, Rosa Estela [2] ; Moron, Antonio Fernandes [4] ; Pereira Sarmento, Stephanno Gomes [5] ; Soriano-Arandes, Antonio [6] ; Passos, Saulo Duarte [1, 2]
Total Authors: 14
Affiliation:
[1] Jundiai Sch Med, Lab Pediat Infectol, Rua Francisco Telles 250, BR-13202550 Jundiai, SP - Brazil
[2] Univ Hosp, Jundiai Sch Med, Jundiai, SP - Brazil
[3] Weill Cornell Med, New York, NY - USA
[4] Paulista Fed Med Sch, Neonatal Perinatal Med Forum, Sao Paulo, SP - Brazil
[5] Paulista Fed Med Sch, Paulista Ctr Fetal Med, Sao Paulo, SP - Brazil
[6] Hosp Univ Vall dHebron, Pediat Infect Dis Unit, Barcelona - Spain
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF NEUROVIROLOGY; v. 26, n. 1, p. 70-76, FEB 2020.
Web of Science Citations: 0
Abstract

Paired maternal and newborn urine and amniotic fluid from 138 subjects collected during a Zika virus (ZIKV) outbreak was analyzed for ZIKV by gene amplification (RT-qPCR), and the findings were correlated with clinical symptoms and neurological anomalies in the babies. ZIKV was detected in 1 of 9 symptomatic women (11.1%) and in 19 of 129 asymptomatic women (14.7%). Neurological manifestations were present in 19 babies (13.7%), 10 of 20 (50%) positive and 9 of 119 (7.6%) negative (p < 0.001) for ZIKV. Twelve (8.6%) urines collected during gestation were ZIKV-positive; only 2 remained positive for ZIKV postpartum. Six (4.1%) newborn urines collected within 1 day of delivery were ZIKV-positive cases. In 3 of these cases, ZIKV was detected in mother's urine pre- and postpartum and in both mother's urine and babies' urine. Four of the amniotic fluid samples (2.9%) were ZIKV-positive. Among ZIKV-negative babies with neurological sequel, 87.5% were female; in contrast, 72.7% ZIKV-positive babies with neurological abnormalities were male (p = 0.019). We conclude that during a ZIKV outbreak, clinical symptoms and ZIKV detection in biological fluids are poor predictors of infection and adverse neurologic sequel in newborns. (AU)

FAPESP's process: 16/08578-0 - Vertical infection by the virus Zika and its impact on the mother-child area
Grantee:Saulo Duarte Passos
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/22007-8 - Vertical infection by the virus Zika and its impact on the mother-child area
Grantee:Danila Vedovello de Jesus
Support type: Scholarships in Brazil - Post-Doctorate