beta(2) adrenergic interaction and cardiac autonomic function: effects of aerobic training in overweight/obese individuals

Author(s)

Lima Rodrigues, Jhennyfer Aline ^{[1, 2]} ; Ferrari, Gustavo Duarte ^[3] ; Trape, Atila Alexandre ^[1] ; de Moraes, Vitor Nolasco ^[4] ; Porto Goncalves, Thiago Correa ^[4] ; Tavares, Simone Sakagute ^[3] ; Tjonna, Arnt Erik ^[5] ; Dutra de Souza, Hugo Celso ^[6] ; Bueno Junior, Carlos Roberto ^{[4, 1]}

Affiliation

^[1] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Bandeirantes Ave 3900, BR-14040907 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Lab Physiol & Metab, Bandeirantes Ave, BR-14040907 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Bandeirantes Ave 3900, BR-14040903 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Clin, Bandeirantes Ave 3900, BR-14040907 Ribeirao Preto, SP - Brazil

^[5] Norwegian Univ Sci & Technol, Fac Med, Dept Circulat & Med Imaging, KG Jebsen Ctr Exercise Med, Trondheim - Norway

^[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Exercise Physiol Lab, Dept Hlth Sci, Bandeirantes Ave, 3900Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 120, n. 3, p. 613-624, MAR 2020.
• Web of Science Citations: 0

Abstract

Purpose To verify the influence of different volumes and intensities of aerobic exercise on cardiac autonomic function (CAF) through heart rate variability (HRV) analysis as well the influence of beta 2 adrenergic receptor (ADRB2) variants in overweight/obese individuals. Methods 70 physically inactive adults were randomly allocated into the following 16-week training: 1-high-intensity interval training (HIIT) (n = 25, 1 x 4 min bout at 85-95%HR peak, 3x/week), 4-HIIT (n = 26, 4 x 4 min bouts at 85-95%HR peak, interspersed with 3 min of recovery at 50-70%HR peak, 3x/week), and moderate continuous training (MCT) (n = 19, 30 min at 60-70%HR peak, 5x/week). Before and after the exercise training, anthropometric, BP, cardiorespiratory fitness, and HRV measures were evaluated. R-R intervals recorded for 10 min in a supine position at pre- and post-intervention were used to analyze HRV in the plot-Poincare indexes (SD1, SD2), and frequency-domain (LF, HF, LF/HF). Full blood samples were used for genotyping. Results 4-HIIT and MCT showed positive outcomes for almost all variables while 1-HIIT had a positive influence only on SBP and SD2 index. No associations were observed between isolated ADRB2 variants and changes in HRV. In the analysis of the interaction genotypes, all groups responded positively for the SD1 index of HRV and only the H1 (GG and CC) and H2 (GG and CG + GG) groups presented increases in the RMSSD index. Furthermore, there was an increase in the LF index only in the H3 (CC and AA + AG) and H4 (AA + AG and CG + GG) groups. Conclusions ADRB2 variants and aerobic exercise training are important interacting variables to improve autonomic function and other health variables outcomes in overweight or obese individuals. (AU)

• FAPESP's process: 13/21159-8 - Influence of genetics polymorphisms in effects of two types of high intensity aerobic interval training in patients with metabolic syndrome
• Grantee: Carlos Roberto Bueno Júnior
• Support Opportunities: Regular Research Grants