The Effect of Particulate Matter Exposure on the Inflammatory Airway Response of Street Runners and Sedentary People

Author(s):Show less -

Pagani, Lucas G. ^[1] ; Santos, Juliana M. B. ^[1] ; Foster, Roberta ^{[1, 2]} ; Rossi, Marcelo ^[1] ; Luna Junior, Luiz A. ^[1] ; Katekaru, Catherine M. ^[1] ; de Sa, Matheus C. ^[1] ; Jonckheere, Anne-Charlotte ^[3] ; Almeida, Francine M. ^[4] ; Amaral, Jonatas B. ^[1] ; Vieira, Rodolfo P. ^{[5, 6, 7, 8]} ; Bullens, Dominique M. A. ^{[3, 9]} ; Bachi, Andre L. L. ^{[5, 1, 2]} ; Vaisberg, Mauro ^[1]

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, Rua Otonis, 700, Piso Super, Second Floor, BR-04025002 Sao Paulo - Brazil

^[2] Method Fac Sao Paulo FAMESP, Av Jabaquara 1314, BR-04046200 Sao Paulo - Brazil

^[3] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, UZ Herestr 49, Box 811, B-3000 Leuven - Belgium

^[4] Univ Sao Paulo, Med Sch, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil

^[5] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil

^[6] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Av Ana Costa 95, BR-11060001 Vila Mathias Santos, SP - Brazil

^[7] Univ Brasil, Postgra Program Bioengn & Biomed Engn, Rua Carolina Fonseca 584, BR-08230030 Itaquera, SP - Brazil

^[8] Anhembi Morumbi Univ, Sch Med, Av Deputado Benedito Matarazzo 6070, BR-04705000 Sao Jose Dos Campos, SP - Brazil

^[9] UZ Leuven, Clin Div Pediat, Herestr 49, B-3000 Leuven - Belgium

• Document type: Journal article
• Source: ATMOSPHERE; v. 11, n. 1 JAN 2020.
• Web of Science Citations: 4

Abstract

Physical exercise promotes many health benefits. However, its effects are not well known in a polluted environment. Thus, this study aimed to compare upper airway inflammatory responses between street runners and sedentary individuals. Twenty-eight volunteers were recruited: runners (n = 14) and sedentary individuals (n = 14), who lived and worked in the same metropolitan area of SAo Paulo, Brazil. Particulate matter (PM) levels were monitored ten weeks before winter (low PM levels) and ten weeks after the beginning of winter (high PM levels) {[}PM10 (p < 0.0001) and PM2.5 (p < 0.0001)]. The cytokines (TNF-alpha, IL-6, IL-10, and IL-17A) levels in the nasal lavage and fractional exhaled nitric oxide (FeNO) were taken at the beginning of the winter (baseline) and ten weeks afterwards (after ten weeks of high PM exposure). IL-6 concentration increased in both runners (p = 0.037) and sedentary individuals (p = 0.027) after high PM exposure compared to the baseline. IL-10 concentration increased in sedentary individuals (p = 0.037) while IL-17A levels were increased in runners (p = 0.001) after high PM exposure compared to the baseline. FeNO levels decreased in runners (p = 0.025) after high PM exposure compared to the baseline. Outdoor endurance training acts as an inducer of a differentiated immune response in the upper airways of runners compared to individuals with a sedentary lifestyle from the same community after elevated PM exposure. (AU)

• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/00307-0 - ASSESSMENT OF THE EFFECTS OF AIR POLLUTION ON STREET RUNNERS AND SEDENTARY IN DIFFERENT ENVIRONMENTAL CONDITIONS
• Grantee: Mauro Walter Vaisberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/04845-3 - EFFECT OF DAILY INTAKE OF Lactobacillus casei Shirota (LcS) IN THE SYSTEMIC AND UPPER AIRWAYS IMMUNE RESPONSIVENESS OF AMATEUR MARATHON RUNNERS WHO PRESENT UPPER RESEPIRATORY SYMPTOMS
• Grantee: André Luis Lacerda Bachi
• Support Opportunities: Regular Research Grants