| Full text | |
| Author(s): |
Chiaratti, Marcos R.
[1]
;
Macabelli, Carolina H.
[1]
;
Augusto Neto, Jose Djaci
[1]
;
Grejo, Mateus Priolo
[1]
;
Pandey, Anand Kumar
[2]
;
Perecin, Felipe
[3]
;
del Collado, Maite
[3]
Total Authors: 7
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Genet & Evolucao, Lab Genet & Biotecnol, Sao Carlos, SP - Brazil
[2] Lala Lajpat Rai Univ Vet & Anim Sci, Hisar, Haryana - India
[3] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Med Vet, Lab Morfofisiol Mol & Desenvolvimento, Pirassununga, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1, 1 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Given the major role of the mitochondrion in cellular homeostasis, dysfunctions of this organelle may lead to several common diseases in humans. Among these, maternal diseases linked to mitochondrial DNA (mtDNA) mutations are of special interest due to the unclear pattern of mitochondrial inheritance. Multiple copies of mtDNA are present in a cell, each encoding for 37 genes essential for mitochondrial function. In cases of mtDNA mutations, mitochondrial malfunctioning relies on mutation load, as mutant and wild-type molecules may co-exist within the cell. Since the mutation load associated with disease manifestation varies for different mutations and tissues, it is hard to predict the progeny phenotype based on mutation load in the progenitor. In addition, poorly understood mechanisms act in the female germline to prevent the accumulation of deleterious mtDNA in the following generations. In this review, we outline basic aspects of mitochondrial inheritance in mammals and how they may lead to maternally-inherited diseases. Furthermore, we discuss potential therapeutic strategies for these diseases, which may be used in the future to prevent their transmission. (AU) | |
| FAPESP's process: | 17/25916-9 - Mitochondrial dysfunctions and DNA damage in oocytes: implications to fertility |
| Grantee: | Marcos Roberto Chiaratti |
| Support type: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 17/19825-0 - Mechanisms of oocyte lipid accumulation in obesity |
| Grantee: | Maite Del Collado Barrondo |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 16/07868-4 - Effect of the mitofusins knockout on the inheritance of deleterious Mitochondrial DNA in mouse embryionic fibroblasts |
| Grantee: | Carolina Habermann Macabelli |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/05899-2 - Effect of the knockout of mitofusins on mouse oocyte: implications to fertility and mitochondrial inheritance |
| Grantee: | Marcos Roberto Chiaratti |
| Support type: | Regular Research Grants |
| FAPESP's process: | 18/13155-6 - Mechanisms of lipid accumulation in oocytes under metabolic altered environments: in vitro maturation and obesity |
| Grantee: | Felipe Perecin |
| Support type: | Regular Research Grants |