Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study

Author(s)

de Oliveira, Aldo S. ^[1] ; de Souza, Luiz F. S. ^[2] ; Nunes, Ricardo J. ^[2] ; Johann, Susana ^[3] ; Palomino-Salcedo, David L. ^[4] ; Ferreira, Leonardo L. G. ^[4] ; Andricopulo, Adriano D. ^[4]

Affiliation

^[1] Fed Univ Santa Catarina UFSC, Dept Exact Sci & Educ, Blumenau, SC - Brazil

^[2] Fed Univ Santa Catarina UFSC, Dept Chem, Florianopolis, SC - Brazil

^[3] Univ Fed Minas Gerais, UFMG, Dept Microbiol, Belo Horizonte, MG - Brazil

^[4] Univ Sao Paulo, Lab Med & Computat Chem, Ctr Res & Innovat Biodivers & Drug Discovery, Inst Phys Sao Carlos, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 20, n. 3, p. 173-181, 2020.
• Web of Science Citations: 1

Abstract

Background: Bacterial resistance to antibiotics is a growing problem in all countries and has been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is highly desirable in the context of medicinal chemistry. Methodology: In this paper we investigate the antioxidant and antibacterial potential of sulfonamides derived from carvacrol, a small molecule with drug-like properties. Most sulfonamides had antioxidant and antibacterial potential, especially compound S-6, derived from beta-naphthylamine. Results: To understand the possible mechanisms of action involved in biological activity, the experimental results were compared with molecular docking data. Conclusion: This research allows appropriate discussion on the identified structure activity relationships. (AU)

• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC