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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats

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Author(s):
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Gomes, Mariana J. [1] ; Pagan, Luana U. [1] ; Lima, Aline R. R. [1] ; Reyes, David R. A. [1] ; Martinez, Paula F. [2] ; Damatto, Felipe C. [1] ; Pontes, Thierres H. D. [1] ; Rodrigues, Eder A. [1] ; Souza, Lidiane M. [1] ; Tosta, Ingrid F. [3] ; Fernandes, Ana A. H. [3] ; Zornoff, Leonardo A. M. [1] ; Okoshi, Katashi [1] ; Okoshi, Marina P. [1]
Total Authors: 14
Affiliation:
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Botucatu, SP - Brazil
[2] Univ Fed Mato Grosso do Sul, Sch Phys Therapy, Campo Grande, MS - Brazil
[3] Sao Paulo State Univ, Inst Biosci, UNESP, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; v. 24, n. 9 APR 2020.
Web of Science Citations: 1
Abstract

We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI-induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S-MI); aerobic exercised MI (A-MI); and resistance exercised MI (R-MI). Exercised rats trained three times a week for 12 weeks on a treadmill or ladder. Statistical analysis was performed by ANOVA or Kruskal-Wallis test. Functional aerobic capacity was greater in A-MI and strength gain higher in R-MI. Echocardiographic parameters did not differ between infarct groups. Reactive oxygen species production, evaluated by fluorescence, was higher in S-MI than Sham, and lipid hydroperoxide concentration was lower in A-MI than the other groups. Glutathione peroxidase activity was higher in A-MI than S-MI and R-MI. Superoxide dismutase was lower in S-MI than Sham and R-MI. Gastrocnemius cross-sectional area, satellite cell activation and expression of the ubiquitin-proteasome system proteins did not differ between groups. In conclusion, aerobic exercise and resistance exercise improve functional capacity and maximum load carrying, respectively, without changing cardiac remodelling in infarcted rats. In the gastrocnemius, infarction increases oxidative stress and changes antioxidant enzyme activities. Aerobic exercise reduces oxidative stress and attenuates superoxide dismutase and glutathione peroxidase changes. (AU)

FAPESP's process: 14/23592-3 - Influence of aerobic or resistance physical exercise on skeletal muscle of rats with myocardial infarction
Grantee:Mariana Janini Gomes
Support type: Scholarships in Brazil - Doctorate