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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation

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Reis, Mouzarllem B. [1] ; Elias-Oliveira, Jefferson [1] ; Pastore, Marcella R. [1] ; Ramos, Simone G. [2] ; Gardinassi, Luiz G. [1] ; Faccioli, Lucia H. [1]
Total Authors: 6
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Sao Paulo - Brazil
[2] Fac Med Ribeirao Preto, Dept Patol & Med Legal, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: TOXINS; v. 12, n. 3 MAR 2020.
Web of Science Citations: 0

Tityus serrulatus causes numerous scorpion envenomation accidents and deaths worldwide. The symptoms vary from local to systemic manifestations, culminating in pulmonary edema and cardiogenic shock. Among these events, transitory hyperglycemia is a severe manifestation that influences pulmonary edema, hemodynamic alterations, and cardiac disturbances. However, the molecular mechanism that leads to increased glucose levels after T. serrulatus envenomation remains unknown. This study aimed to investigate our hypothesis that hyperglycemia due to scorpion envenomation involves inflammatory signaling in the pancreas. The present study showed that T. serrulatus venom induces the production of IL-1 alpha and IL-1 beta in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in beta-cells in islets. Il1r1(-/-) mice were protected from transitory hyperglycemia and did not present disturbances in insulin levels in the serum. These results suggest that the pathway driven by IL-1 alpha/IL-1 beta-IL-1R-NO inhibits insulin release by beta-cells, which increases systemic glucose concentration during severe scorpion envenomation. A supportive therapy that inhibits NO production, combined with antiserum, may help to prevent fatal outcomes of scorpion envenomation. Our findings provide novel insights into the design of supportive therapy with NO inhibitors combined with antiscorpion venom serum to overcome fatal outcomes of scorpion envenomation. (AU)

FAPESP's process: 17/02314-3 - Investigation of cardiac changes that occur in poisoning by Tityus serrulatus scorpion venom
Grantee:Mouzarllem Barros dos Reis
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/07125-6 - New functional aspects of eicosanoids
Grantee:Lúcia Helena Faccioli
Support type: Research Projects - Thematic Grants