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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

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Author(s):
Urzedo, Alessandro L. [1] ; Goncalves, Marcelly C. [2] ; Nascimento, Monica H. M. [1] ; Lombello, Christiane B. [3] ; Nakazato, Gerson [2] ; Seabra, Amedea B. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Abc, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Estadual Londrina, Dept Microbiol, Campus Univ, BR-86055990 Londrina, Parana - Brazil
[3] Univ Fed Abc, Ctr Engn Modeling & Appl Social Sci, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ACS BIOMATERIALS SCIENCE & ENGINEERING; v. 6, n. 4, p. 2117-2134, APR 2020.
Web of Science Citations: 5
Abstract

Nitric oxide (NO) and silver nanoparticles (AgNPs) are well-known for their antibacterial activity. In this work, S-nitroso-mercaptosuccinic acid (S-nitroso-MSA), a NO donor, and green tea synthesized AgNPs were individually or simultaneously incorporated into alginate hydrogel for topical antibacterial applications. The obtained hydrogels were characterized and the NO release and diffusion of AgNPs and S-nitroso-MSA from alginate hydrogels were investigated. The hydrogels showed a concentration dependent toxicity toward Vero cells. The potent antibacterial effect of the hydrogels was demonstrated toward Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, and Streptococcus mutans UA159. Interestingly, the combination of S-nitroso-MSA and AgNPs into alginate hydrogels had a superior antibacterial effect, compared with hydrogels containing S-nitroso-MSA or AgNPs individually. This is the first report to describe the synthesis, cytotoxicity, and antibacterial effects of alginate hydrogel containing NO donor and AgNPs. These hydrogels might find important local applications in the combat of bacterial infections. (AU)

FAPESP's process: 18/08194-2 - Essential oil amended with metal nanoparticles functionalized with nitric oxide as a strategy to control plant pathogens in the agriculture
Grantee:Amedea Barozzi Seabra
Support Opportunities: Regular Research Grants