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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

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Author(s):
Santos, Soraya Silva [1] ; de Araujo, Renan Vinicius [1] ; Giarolla, Jeanine [1] ; El Seoud, Omar [1] ; Ferreira, Elizabeth Igne [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Potentially Act, Ave Prof Lineu Prestes, 580 Bldg 13, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS; v. 55, n. 4 APR 2020.
Web of Science Citations: 0
Abstract

Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are a considerable global challenge. Despite the huge number of people infected, NDs do not create interest from pharmaceutical companies because the associated revenue is generally low. Most of the research on these diseases has been conducted in academic institutions. The chemotherapeutic armamentarium for NDs is scarce and inefficient and better drugs are needed. Researchers have found some promising potential drug candidates using medicinal chemistry and computational approaches. Most of these compounds are synthetic but some are from natural sources or are semi-synthetic. Drug repurposing or repositioning has also been greatly stimulated for NDs. This review considers some potential drug candidates and provides details of their design, discovery and activity. (C) 2020 Published by Elsevier B.V. (AU)

FAPESP's process: 15/19438-1 - Synthesis and studies of bioactive compounds release from dendrimer prodrugs and targeted drugs potentially active in neglected diseases
Grantee:Jeanine Giarolla Vargas
Support Opportunities: Regular Research Grants
FAPESP's process: 17/21154-7 - First generation polyamidoamine (PAMAM): design and synthesis of a potentially active tuberculosis prodrug
Grantee:Renan Vinicius de Araujo
Support Opportunities: Scholarships in Brazil - Scientific Initiation