Chemical composition and antimycoplasma activity of a brown propolis from southern Brazil

Author(s)

Araujo, Camila do Nascimento ^[1] ; Sivero Mayworm, Marco Aurelio ^[1] ; Yatsuda, Regiane ^[2] ; Negri, Giuseppina ^[3] ; Faria Salatino, Maria Luiza ^[3] ; Salatino, Antonio ^[3] ; Timenetsky, Jorge ^[4] ; Campos, Guilherme Barreto ^[2]

Affiliation

^[1] Univ Santo Amaro, Rua Prof Eneas de Siqueira Neto 340, Sao Paulo 04829300, SP - Brazil

^[2] Univ Fed Bahia, Inst Multidisciplinar Saude, Campus Anisio Teixeira, Rua Hormindo Barros 58, Vitoria Da Conquista 45029094, BA - Brazil

^[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, Rua Matao 277, Sao Paulo 05508090, SP - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Av Prof Lineu Prestes 1374, Sao Paulo 05508090, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE; v. 57, n. 11 APR 2020.
• Web of Science Citations: 4

Abstract

Extracts of a sample of brown propolis produced in the district of Itapara (Southern Brazil) were obtained with solvents with increasing polarity. The extracts were analyzed by RPHPLC-DAD-ESI-MS/MS and evaluated toward activity against Mycoplasma bovis, M. gallisepticum, M. genitalium, M. hominis, M. hyorinis, M. penetrans and M. pneumonieae. Typical components of ``alecrim-do-campo{''} propolis (e.g. prenylated phenylpropanoids and caffeoyl-quinic acids) were characterized in the analyzed extraccts, in addition to several flavonols. Less polar extracts showed higher anti-mycoplasma activity (MIC value commonly 3.9 mu g/mL) than alcoholic and aqueous extracts (MIC value often 7.8-250 mu g/mL). The results indicate that Itapara propolis is a promising source for the development of therapeutic drugs. (AU)

• FAPESP's process: 13/21813-0 - Chemical characterization of two samples of Brazilian propolis and their biological properties
• Grantee: Antonio Salatino
• Support Opportunities: Regular Research Grants