| Full text | |
| Author(s): |
Alexsandra Conceição Apolinário
[1]
;
Giovanna Cassone Salata
[2]
;
Arthur F. R. Bianco
[3]
;
Claudio Fukumori
[4]
;
Luciana Biagini Lopes
[5]
Total Authors: 5
|
| Affiliation: | [1] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia - Brasil
[2] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia - Brasil
[3] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia - Brasil
[4] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia - Brasil
[5] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia - Brasil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Química Nova; v. 43, n. 2, p. 212-225, 2020-05-18. |
| Abstract | |
Limitations of conventional treatment and dosage forms prompted the investigation of novel approaches that combine efficacy, selectivity and fewer adverse effects. These are the main promises of nanomedicine, generally defined as the application of nanotechnology to the biomedical field. Despite the considerable advances over the years and the large number of publications resulting from the growth of nanomedicine, there are still many hurdles and unknown factors limiting its successful translation from promise to reality. These factors range from the lack of standardization in the terminology and regulations, to the lack of understanding of interactions between nanocarriers and the biological system, and their influence on drug pharmacodynamics. In this manuscript, we aim at presenting and discussing concepts and terminologies used in the nanomedicine field and examining the main types of nanocarriers and their effects to modulate biological barriers and aid drug transport, bioavailability and targeting. (AU) | |
| FAPESP's process: | 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors |
| Grantee: | Luciana Biagini Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 17/23213-0 - Biorresponsive systems for sustained drug release and breast cancer chemoprevention |
| Grantee: | Giovanna Cassone Salata |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 18/14375-0 - Nanotechnology-based topical delivery systems for breast cancer chemoprevention |
| Grantee: | Alexsandra Conceição Apolinário |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach |
| Grantee: | Maria Vitória Lopes Badra Bentley |
| Support Opportunities: | Research Projects - Thematic Grants |