Phototherapy on Management of Creatine Kinase Activity in General Versus Localized Exercise: A Systematic Review and Meta-Analysis

Author(s)

Machado, Aryane Flauzino ^[1] ; Micheletti, Jessica Kirsch ^[1] ; Lopes, Jaqueline Santos Silva ^[1] ; Vanderlei, Franciele Marques ^[1] ; Leal-Junior, Ernesto Cesar Pinto ^[2] ; Netto Junior, Jayme ^[1] ; Pastre, Carlos Marcelo ^[1]

Affiliation

^[1] Univ Estadual Paulista, Postgrad Program Physiotherapy, Dept Physiotherapy, Fac Ciencias & Tecnol, Presidente Prudente - Brazil

^[2] Nove Julho Univ Sao Paulo, Lab Phototherapy Sports & Exercise, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

• Document type: Review article
• Source: CLINICAL JOURNAL OF SPORT MEDICINE; v. 30, n. 3, p. 267-274, MAY 2020.
• Web of Science Citations: 3

Abstract

Objective: The main focus of this systematic review was to determine the efficacy of phototherapy in the management of creatine kinase (CK) activity after exercise and furthermore to identify for which exercise model protocol phototherapy provides the best results. Design: Meta-analysis comparing phototherapy with a control condition. Setting: The MEDLINE, EMBASE, SPORTDiscus, PEDro, and CENTRAL databases were searched from their earliest records to October 03, 2016. Data were pooled in a meta-analysis and described as standardized mean difference (SMD) with 95% confidence intervals (CIs) using a random effects model. Participants: Healthy subjects (no restrictions were applied, eg, age, sex, and exercise level). Intervention: Phototherapy (low-level laser therapy and/or light-emitting diode therapy) before or after exercise and a placebo or control condition. Main Outcome Measures: Creatine kinase activity (no restriction to any analysis, eg, serum, plasma, or capillary blood). Results: Fourteen studies were included for review. The results revealed that phototherapy has a more positive effect than control condition in management of CK activity {[}SMD = 0.77, 95% CI (0.32 to 1.22); P = 0.0007; I-2 = 72%]. In exploratory analysis, the results showed that phototherapy was effective only in the exercise protocol with localized exercise with large effect size {[}localized exercise: SMD = 0.89, 95% CI (0.26 to 1.51); P = 0.0002; I-2 = 76%; general exercise: SMD = 0.61, 95% CI (-0.05 to 1.26); P = 0.07; I-2 = 67%]. Conclusions: The available evidence suggest that phototherapy has beneficial effects on the management of CK activity and demonstrate a possible relationship based on damage caused by exercise, providing a greater effect in studies that used localized exercise. (AU)

• FAPESP's process: 15/25219-0 - Effects of phototherapy in recovery of clinical, psychological, functional outcomes and vascular endothelial growth: a clinical trial randomized by stratified sample, double blind, placebo-controlled
• Grantee: Aryane Flauzino Machado
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/25220-9 - Phototherapy in post-exercise recovery and performance: stratified randomized controlled trial, double-blind, placebo-controlled
• Grantee: Carlos Marcelo Pastre
• Support Opportunities: Regular Research Grants