Skeletal muscle fatigue and recovery are novel areas of research in Low-Level Laser Therapy (LLLT). Recent studies of our research group with phototherapy have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle recovery when these therapies were applied before exercise. However, several factors still remain unknown such as: optimal doses and treatment parameters, mechanisms of action, effects in mild and long-term, and "therapeutic windows" that radiation with different wavelengths could have. With these factors in mind, the aims of this project are: to evaluate the effects of LLLT in skeletal muscle fatigue; to evaluate the effects of LLLT in muscular activity-induced skeletal muscle damage; and to identify dose-response patterns establishing the optimal doses of 660 nm, 830 nm and 905 nm LLLT previously to muscular activity. For such, we will perform an animal experiment. In this animal experiment we will employ a tetanic contractions protocol to induce skeletal muscle fatigue in tibialis anterior muscle of animals. Previously to protocol animals will be irradiated with 660 nm, 830 nm or 905 nm LLLT (both with 50 mW) at one of 3 different doses (1.0 J; 3.0 J; or 10.0 J). We will evaluate outcomes related to skeletal muscle performance (force peak, time to decay 50% of peak force, and muscular work), morphology of skeletal muscle (histology), and biochemical markers related to skeletal muscle damage (Creatine Kinase - CK).
News published in Agência FAPESP Newsletter about the scholarship: