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Low-level laser therapy in skeletal muscle fatigue and post-exercise recovery: Optimal parameters and effects in long-duration exercise

Abstract

Skeletal muscle fatigue and recovery is a novel area of research in Low-Level Laser Therapy (LLLT). Recent studies of our research group with phototherapy have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle recovery when these therapies were applied before exercise. However, several factors still remain unknown such as: optimal doses and treatment parameters, mechanisms, the effects in long-duration exercises and long-term effects in skeletal muscle recovery. With these in mind, the aims of this project are: To evaluate the long-term effects of LLLT in post-exercise skeletal muscle recovery, to identify the optimal dose of LLLT, to identify the optimal output power / irradiation time (from best dose), and to evaluate the effects of LLLT in skeletal muscle fatigue and recovery in long-duration exercise. It will be performed 3 randomized double-blind placebo-controlled trials, with voluntary participation of high-level soccer athletes. We will analyze parameters related to volunteers exercise performance (muscular force / maximum voluntary contraction - MVC, VO2max and fatigue index), delayed onset muscle soreness (DOMS), and biochemical markers of muscle damage (CK and LDH), inflammation (IL-1, IL-6 and TNF-α) and oxidative stress (TBARS, CAT, SOD and carbonyled proteins). The analysis will be performed before exercise protocols, after 1 minute, and 1, 24, 48, 72 e 96 hours after the end of exercise protocols. (AU)

Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIRANDA, EDUARDO FOSCHINI; DINIZ, WELTON ALVES; NOGUEIRA GOMES, MARCOS VINICIUS; DUARTE DE OLIVEIRA, MARCELO FERREIRA; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Acute effects of photobiomodulation therapy (PBMT) combining laser diodes, light-emitting diodes, and magnetic field in exercise capacity assessed by 6MST in patients with COPD: a crossover, randomized, and triple-blinded clinical trial. Lasers in Medical Science, v. 34, n. 4, p. 711-719, JUN 2019. Web of Science Citations: 0.
LANGELLA, LUCIANA GONCALVES; CASALECHI, HELIODORA LEAO; TOMAZONI, SHAIANE SILVA; JOHNSON, DOUGLAS SCOTT; ALBERTINI, REGIANE; PALLOTTA, RODNEY CAPP; MARCOS, RODRIGO LABAT; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplastya randomized, triple-blind, placebo-controlled clinical trial. Lasers in Medical Science, v. 33, n. 9, p. 1933-1940, DEC 2018. Web of Science Citations: 6.
ALBUQUERQUE-PONTES, GIANNA MOES; CASALECHI, HELIODORA LEAO; TOMAZONI, SHAIANE SILVA; SERRA, ANDREY JORGE; BACELAR FERREIRA, CHEILA DE SOUSA; DE OLIVEIRA BRITO, RODRIGO BARBOSA; DE MELO, BRUNNO LEMES; VANIN, ADRIANE AVER; DAMASCENO SOARES MONTEIRO, KADMA KARENINA; DELLE, HUMBERTO; FRIGO, LUCIO; MARCOS, RODRIGO LABAT; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Photobiomodulation therapy protects skeletal muscle and improves muscular function of mdx mice in a dose-dependent manner through modulation of dystrophin. Lasers in Medical Science, v. 33, n. 4, p. 755-764, MAY 2018. Web of Science Citations: 4.
MIRANDA, EDUARDO FOSCHINI; TOMAZONI, SHAIANE SILVA; VICENTE DE PAIVA, PAULO ROBERTO; PINTO, HENRIQUE DANTAS; SMITH, DENIS; SANTOS, LARISSA ALINE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. When is the best moment to apply photobiomodulation therapy (PBMT) when associated to a treadmill endurance-training program? A randomized, triple-blinded, placebo-controlled clinical trial. Lasers in Medical Science, v. 33, n. 4, p. 719-727, MAY 2018. Web of Science Citations: 7.
VANIN, ADRIANE AVER; VERHAGEN, EVERT; BARBOZA, SAULO DELFINO; PENA COSTA, LEONARDO OLIVEIRA; PINTO LEAL-JUNIOR, ERNESTO CESAR. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers in Medical Science, v. 33, n. 1, p. 181-214, JAN 2018. Web of Science Citations: 25.
DE OLIVEIRA, ADRIANO RODRIGUES; VANIN, ADRIANE AVER; TOMAZONI, SHAIANE SILVA; MIRANDA, EDUARDO FOSCHINI; ALBUQUERQUE-PONTES, GIANNA MOES; DE MARCHI, THIAGO; GRANDINETTI, VANESSA DOS SANTOS; VICENTE DE PAIVA, PAULO ROBERTO; GONCALVES IMPERATORI, TREICE BEATRIZ; CAMILLO DE CARVALHO, PAULO DE TARSO; BJORDAL, JAN MAGNUS; PINTO LEAL-JUNIOR, ERNESTO CESAR. Pre-Exercise Infrared Photobiomodulation Therapy (810nm) in Skeletal Muscle Performance and Postexercise Recovery in Humans: What Is the Optimal Power Output?. Photomedicine and Laser Surgery, v. 35, n. 11, SI, p. 595-603, NOV 2017. Web of Science Citations: 8.
VICENTE DE PAIVA, PAULO ROBERTO; TOMAZONI, SHAIANE SILVA; JOHNSON, DOUGLAS SCOTT; VANIN, ADRIANE AVER; ALBUQUERQUE-PONTES, GIANNA MOES; MONTEIRO MACHADO, CAROLINE DOS SANTOS; CASALECHI, HELIODORA LEO; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Photobiomodulation therapy (PBMT) and/or cryotherapy in skeletal muscle restitution, what is better? A randomized, double-blinded, placebo-controlled clinical trial. Lasers in Medical Science, v. 31, n. 9, p. 1925-1933, DEC 2016. Web of Science Citations: 15.
VANIN, ADRIANE AVER; MIRANDA, EDUARDO FOSCHINI; MONTEIRO MACHADO, CAROLINE SANTOS; VICENTE DE PAIVA, PAULO ROBERTO; ALBUQUERQUE-PONTES, GIANNA MOES; CASALECHI, HELIODORA LEAO; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. What is the best moment to apply phototherapy when associated to a strength training program? A randomized, double-blinded, placebo-controlled trial. Lasers in Medical Science, v. 31, n. 8, p. 1555-1564, NOV 2016. Web of Science Citations: 23.
VANIN, ADRIANE AVER; DE MARCHI, THIAGO; TOMAZONI, SHAIANE SILVA; TAIROVA, OLGA; CASALECHI, HELIODORA LEAO; CAMILLO DE CARVALHO, PAULO DE TARSO; BJORDAL, JAN MAGNUS; LEAL-JUNIOR, ERNESTO CESAR. Pre-Exercise Infrared Low-Level Laser Therapy (810nm) in Skeletal Muscle Performance and Postexercise Recovery in Humans, What Is the Optimal Dose? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Photomedicine and Laser Surgery, v. 34, n. 10, p. 473-482, OCT 2016. Web of Science Citations: 17.
MIRANDA, EDUARDO FOSCHINI; VANIN, ADRIANE AVER; TOMAZONI, SHAIANE SILVA; GRANDINETTI, VANESSA DOS SANTOS; VICENTE DE PAIVA, PAULO ROBERTO; MONTEIRO MACHADO, CAROLINE DOS SANTOS; DAMASCENO SOARES MONTEIRO, KADMA KARENINA; CASALECHI, HELIODORA LEAO; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests. JOURNAL OF ATHLETIC TRAINING, v. 51, n. 2, p. 129-135, FEB 2016. Web of Science Citations: 21.
PINTO LEAL-JUNIOR, ERNESTO CESAR; VANIN, ADRIANE AVER; MIRANDA, EDUARDO FOSCHINI; CAMILLO DE CARVALHO, PAULO DE TARSO; DAL CORSO, SIMONE; BJORDAL, JAN MAGNUS. Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis. Lasers in Medical Science, v. 30, n. 2, p. 925-939, FEB 2015. Web of Science Citations: 74.
ALBUQUERQUE-PONTES, GIANNA MOES; VIEIRA, RODOLFO DE PAULA; TOMAZONI, SHAIANE SILVA; CAIRES, CLAUDIA OLIVEIRA; NEMETH, VICTORIA; VANIN, ADRIANE AVER; SANTOS, LARISSA ALINE; PINTO, HENRIQUE DANTAS; MARCOS, RODRIGO LABAT; BJORDAL, JAN MAGNUS; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Effect of pre-irradiation with different doses, wavelengths, and application intervals of low-level laser therapy on cytochrome c oxidase activity in intact skeletal muscle of rats. Lasers in Medical Science, v. 30, n. 1, p. 59-66, JAN 2015. Web of Science Citations: 44.
MIRANDA, EDUARDO FOSCHINI; FRANCO DE OLIVEIRA, LUIS VICENTE; ANTONIALLI, FERNANDA COLELLA; VANIN, ADRIANE AVER; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Phototherapy with combination of super-pulsed laser and light-emitting diodes is beneficial in improvement of muscular performance (strength and muscular endurance), dyspnea, and fatigue sensation in patients with chronic obstructive pulmonary disease. Lasers in Medical Science, v. 30, n. 1, p. 437-443, JAN 2015. Web of Science Citations: 17.
ANTONIALLI, FERNANDA COLELLA; DE MARCHI, THIAGO; TOMAZONI, SHAIANE SILVA; VANIN, ADRIANE AVER; GRANDINETTI, VANESSA DOS SANTOS; VICENTE DE PAIVA, PAULO ROBERTO; PINTO, HENRIQUE DANTAS; MIRANDA, EDUARDO FOSCHINI; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Phototherapy in skeletal muscle performance and recovery after exercise: effect of combination of super-pulsed laser and light-emitting diodes. Lasers in Medical Science, v. 29, n. 6, p. 1967-1976, NOV 2014. Web of Science Citations: 46.
SANTOS, LARISSA ALINE; MARCOS, RODRIGO LABAT; TOMAZONI, SHAIANE SILVA; VANIN, ADRIANE AVER; ANTONIALLI, FERNANDA COLELLA; GRANDINETTI, VANESSA DOS SANTOS; ALBUQUERQUE-PONTES, GIANNA MOES; VICENTE DE PAIVA, PAULO ROBERTO; BRANDAO LOPES-MARTINS, RODRIGO ALVARO; CAMILLO DE CARVALHO, PAULO DE TARSO; BJORDAL, JAN MAGNUS; PINTO LEAL-JUNIOR, ERNESTO CESAR. Effects of pre-irradiation of low-level laser therapy with different doses and wavelengths in skeletal muscle performance, fatigue, and skeletal muscle damage induced by tetanic contractions in rats. Lasers in Medical Science, v. 29, n. 5, p. 1617-1626, SEP 2014. Web of Science Citations: 35.
DOS SANTOS, SOLANGE ALMEIDA; ARARUNA ALVES, ANA CAROLINA; PINTO LEAL-JUNIOR, ERNESTO CESAR; ALBERTINI, REGIANE; VIEIRA, RODOLFO DE PAULA; LIGEIRO, ANA PAULA; SILVA JUNIOR, JOSE ANTONIO; CAMILLO DE CARVALHO, PAULO DE TARSO. Comparative analysis of two low-level laser doses on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. Lasers in Medical Science, v. 29, n. 3, p. 1051-1058, MAY 2014. Web of Science Citations: 30.
PINTO LEAL-JUNIOR, ERNESTO CESAR; DE ALMEIDA, PATRICIA; TOMAZONI, SHAIANE SILVA; CAMILLO DE CARVALHO, PAULO DE TARSO; BRANDAO LOPES-MARTINS, RODRIGO ALVARO; FRIGO, LUCIO; JOENSEN, JON; JOHNSON, MARK I.; BJORDAL, JAN MAGNUS. Superpulsed Low-Level Laser Therapy Protects Skeletal Muscle of mdx Mice against Damage, Inflammation and Morphological Changes Delaying Dystrophy Progression. PLoS One, v. 9, n. 3 MAR 5 2014. Web of Science Citations: 19.
DE ALMEIDA, PATRICIA; TOMAZONI, SHAIANE SILVA; FRIGO, LUCIO; CAMILLO DE CARVALHO, PAULO DE TARSO; VANIN, ADRIANE AVER; SANTOS, LARISSA ALINE; ALBUQUERQUE-PONTES, GIANNA MOES; DE MARCHI, THIAGO; TAIROVA, OLGA; MARCOS, RODRIGO LABAT; BRANDAO LOPES-MARTINS, RODRIGO ALVARO; PINTO LEAL-JUNIOR, ERNESTO CESAR. What is the best treatment to decrease pro-inflammatory cytokine release in acute skeletal muscle injury induced by trauma in rats: low-level laser therapy, diclofenac, or cryotherapy?. Lasers in Medical Science, v. 29, n. 2, SI, p. 653-658, MAR 2014. Web of Science Citations: 30.
DE OLIVEIRA, ADRIANO RODRIGUES; VANIN, ADRIANE AVER; DE MARCHI, THIAGO; ANTONIALLI, FERNANDA COLELLA; GRANDINETTI, VANESSA DOS SANTOS; VICENTE DE PAIVA, PAULO ROBERTO; ALBUQUERQUE PONTES, GIANNA MOES; SANTOS, LARISSA ALINE; ALEIXO JUNIOR, IVO DE OLIVEIRA; CAMILLO DE CARVALHO, PAULO DE TARSO; BJORDAL, JAN MAGNUS; PINTO LEAL-JUNIOR, ERNESTO CESAR. What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial. Trials, v. 15, FEB 27 2014. Web of Science Citations: 4.
MIRANDA, EDUARDO FOSCHINI; PINTO LEAL-JUNIOR, ERNESTO CESAR; MARCHETTI, PAULO HENRIQUE; DAL CORSO, SIMONE. Acute effects of light emitting diodes therapy (LEDT) in muscle function during isometric exercise in patients with chronic obstructive pulmonary disease: preliminary results of a randomized controlled trial. Lasers in Medical Science, v. 29, n. 1, p. 359-365, JAN 2014. Web of Science Citations: 25.
DE ALMEIDA, PATRICIA; BRANDAO LOPES-MARTINS, RODRIGO ALVARO; TOMAZONI, SHAIANE SILVA; ALBUQUERQUE-PONTES, GIANNA MOES; SANTOS, LARISSA ALINE; VANIN, ADRIANE AVER; FRIGO, LUCIO; VIEIRA, RODOLFO P.; ALBERTINI, REGIANE; CAMILLO DE CARVALHO, PAULO DE TARSO; PINTO LEAL-JUNIOR, ERNESTO CESAR. Low-Level Laser Therapy and Sodium Diclofenac in Acute Inflammatory Response Induced by Skeletal Muscle Trauma: Effects in Muscle Morphology and mRNA Gene Expression of Inflammatory Markers. Photochemistry and Photobiology, v. 89, n. 2, p. 501-507, MAR-APR 2013. Web of Science Citations: 25.

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