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Low-level laser therapy in skeletal muscle fatigue and post-exercise recovery: What is the ideal dose?

Grant number: 12/02442-8
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Ernesto Cesar Pinto Leal Junior
Grantee:Adriane Aver Vanin
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated research grant:10/52404-0 - Low-level laser therapy in skeletal muscle fatigue and post-exercise recovery: Optimal parameters and effects in long-duration exercise, AP.JP


Skeletal muscle fatigue and recovery is a novel area of research in Low-Level Laser Therapy (LLLT). Recent studies of our research group with phototherapy have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle recovery when these therapies were applied before exercise. However, several factors still remain unknown such as: optimal doses and treatment parameters, mechanisms, the effects in long-duration exercises and long-term effects in skeletal muscle recovery. With these factors in mind, the aims of this project are: To evaluate the long-term effects of LLLT in post-exercise skeletal muscle recovery and to identify the optimal dose of LLLT. It will be performed a randomized, double-blinded, placebo-controlled trial, with voluntary participation of high-level soccer athletes. We will analyse parameters related to volunteers exercise performance (torque peak / maximum voluntary contraction - MVC), delayed onset muscle soreness (DOMS), and biochemical markers of muscle damage (CK and LDH), inflammation (IL-1, IL-6 and TNF-±) and oxidative stress (TBARS, CAT, SOD and carbonyled proteins). The analysis will be performed before exercise protocols, after 1 minute, and 1, 24, 48, 72 and 96 hours after the end of exercise protocol.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VANIN, ADRIANE AVER; DE MARCHI, THIAGO; TOMAZONI, SHAIANE SILVA; TAIROVA, OLGA; CASALECHI, HELIODORA LEAO; CAMILLO DE CARVALHO, PAULO DE TARSO; BJORDAL, JAN MAGNUS; LEAL-JUNIOR, ERNESTO CESAR. Pre-Exercise Infrared Low-Level Laser Therapy (810nm) in Skeletal Muscle Performance and Postexercise Recovery in Humans, What Is the Optimal Dose? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Photomedicine and Laser Surgery, v. 34, n. 10, p. 473-482, . (12/02442-8, 10/52404-0, 13/19355-3)
PINTO LEAL-JUNIOR, ERNESTO CESAR; VANIN, ADRIANE AVER; MIRANDA, EDUARDO FOSCHINI; CAMILLO DE CARVALHO, PAULO DE TARSO; DAL CORSO, SIMONE; BJORDAL, JAN MAGNUS. Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis. Lasers in Medical Science, v. 30, n. 2, p. 925-939, . (12/02442-8, 10/52404-0)

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