Real-Time Non-invasive Assessment of Cerebral Hemodynamics With Diffuse Optical Spectroscopies in a Neuro Intensive Care Unit: An Observational Case Study

Author(s)

Forti, Rodrigo M. ^{[1, 2]} ; Katsurayama, Marilise ^{[2, 3]} ; Menko, Julien ^[4] ; Valler, Lenise ^{[2, 3]} ; Quiroga, Andres ^{[1, 2]} ; Falcao, Antonio L. E. ^[3] ; Li, Li M. ^{[5, 2]} ; Mesquita, Rickson C. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Inst Phys, Campinas - Brazil

^[2] Brazilian Inst Neurosci & Neurotechnol, Campinas - Brazil

^[3] Univ Estadual Campinas, Clin Hosp, Campinas - Brazil

^[4] Albert Einstein Coll Med, Dept Emergency Med, Bronx, NY 10467 - USA

^[5] Univ Estadual Campinas, Sch Med Sci, Campinas - Brazil

• Document type: Journal article
• Source: FRONTIERS IN MEDICINE; v. 7, APR 28 2020.
• Web of Science Citations: 0

Abstract

Prevention of secondary damage is an important goal in the treatment of severe neurological conditions, such as major head trauma or stroke. However, there is currently a lack of non-invasive methods for monitoring cerebral physiology. Diffuse optical methods have been proposed as an inexpensive, non-invasive bedside monitor capable of providing neurophysiology information in neurocritical patients. However, the reliability of the technique to provide accurate longitudinal measurement during the clinical evolution of a patient remains largely unaddressed. Here, we report on the translation of a hybrid diffuse optical system combining frequency domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) for real-time monitoring of cerebral physiology in a neuro intensive care unit (neuro-ICU). More specifically, we present a case study of a patient admitted with a high-grade aneurysmal subarachnoid hemorrhage, who was monitored throughout hospitalization. We show that the neurophysiological parameters measured by diffuse optics at the bedside are consistent with the clinical evolution of the patient at all the different stages following its brain lesion. These data provide support for clinical translation of DOS/DCS as a useful biomarker of neurophysiology in the neuro-ICU, particularly in locations where other clinical resources are limited. (AU)

• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies
• Grantee: Rickson Coelho Mesquita
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/25486-6 - Construction and evaluation of a frequency-domain diffuse optical spectroscopy device for brain monitoring in the clinic
• Grantee: Rodrigo Menezes Forti
• Support Opportunities: Scholarships in Brazil - Doctorate