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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Approaches for Cryptococcosis Treatment

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Author(s):
Spadari, Cristina de Castro [1] ; Wirth, Fernanda [1] ; Lopes, Luciana Biagini [2] ; Ishida, Kelly [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Antifungal Chemotherapy, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Lab Nanomed & Drug Delivery Syst, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: MICROORGANISMS; v. 8, n. 4 APR 2020.
Web of Science Citations: 7
Abstract

Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine. In addition to the limited pharmacological options, the high toxicity, increased resistance rate and difficulty of the currently available antifungal molecules to cross the blood-brain barrier hamper the treatment. Thus, the search for new alternatives for the treatment of cryptococcal meningitis is extremely necessary. In this review, we describe the therapeutic strategies currently available, discuss new molecules with antifungal potential in different phases of clinical trials and in advanced pre-clinical phase, and examine drug nanocarriers to improve delivery to the central nervous system. (AU)

FAPESP's process: 17/19374-9 - Echinocandins in the control of infections associated to polymicrobial biofilms of Candida spp. and bacteria such as Stapholococcus aureus and Pseudomonas aeruginosa
Grantee:Kelly Ishida
Support Opportunities: Regular Research Grants
FAPESP's process: 18/12149-2 - Nanoparticles as carriers of miltefosine for treatment of cryptococcal meningitis.
Grantee:Cristina de Castro Spadari
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors
Grantee:Luciana Biagini Lopes
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2