Space charge effects and internal standardization in a four ion lenses interface: What is changing in quadrupole inductively coupled plasma mass spectrometry?

Author(s)

Barros, Ariane I. ^[1] ; Pinheiro, Fernanda C. ^[1] ; Nobrega, Joaquim A. ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Chem, Grp Appl Instrumental Anal, POB 676, BR-13560270 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY; v. 167, MAY 2020.
• Web of Science Citations: 0

Abstract

Space charge effects and internal standardization were evaluated in quadrupole inductively coupled plasma mass spectrometry (ICP-MS). Changes in analyte ion sensitivities as a function of analyte ion mass (B-11(+), Mg-24(+), Sc-45(+), Ni-60(+), Ga-71(+), As-75(+), Cd-111(+), Ba-138(+) and Yb-172(+)) due to the presence of seven different matrix elements (Na-23(+), Cu-63(+), Y-89(+), In-115(+), Tb-159(+), Lu-175(+) and Tl-205(+)) were measured by a current ICP-MS instrument arrangement. Elements with different masses (light, middle and high mass range) were evaluated as internal standard (IS): Li-7(+), Sr-88(+) and Bi-209(+). Space charge effects generally becomes more severe for matrices containing elements with middle mass (In-115(+)) and high masses (Tb-159(+), Lu-175(+) and Tl-205(+)) but are not dependent on the masses of most analyte ions, differently from which was known about space charge effects when using first generation ICP-MS instruments. Thus, a single IS was effective for minimize the matrix induced changes (range from -20 to +20%) for analytes with different masses in In matrix (except to mass-to-charge ratio lower than 50); Tb matrix (except to Li-7(+)); Lu matrix (except to Yb-175(+)); and Tl matrix (except to Mg-25(+)). (AU)

• FAPESP's process: 14/50951-4 - INCT 2014: Advanced Analytical Technologies
• Grantee: Celio Pasquini
• Support Opportunities: Research Projects - Thematic Grants