Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

Full text
Author(s):
Deda, Daiana K. [1] ; Iglesias, Bernardo A. [2] ; Alves, Eduardo [3] ; Araki, Koiti [1] ; Garcia, Celia R. S. [4]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Santa Maria, Bioinorgan & Porphyrinoid Mat Lab, Dept Chem, Ave Roraima 1000, BR-97105900 Santa Maria, RS - Brazil
[3] Imperial Coll London, Dept Life Sci, Sir Alexander Fleming Bldg, London SW7 2AZ - England
[4] Univ Sao Paulo, Dept Clin & Toxicol Anal, Sch Pharmaceut Sci, Ave Prof Lineu Prestes 580, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: Molecules; v. 25, n. 9 MAY 2020.
Web of Science Citations: 0
Abstract

Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature. (AU)

FAPESP's process: 17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/07177-7 - EMU concedido no processo 2011/51295-5: image system
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 18/21489-1 - Supramolecular nanotechnology: design, materials and devices
Grantee:Henrique Eisi Toma
Support Opportunities: Research Projects - Thematic Grants