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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Phylum Bryozoa: From Biology to Biomedical Potential

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Author(s):
Ciavatta, Maria Letizia [1] ; Lefranc, Florence [2] ; Vieira, Leandro M. [3] ; Kiss, Robert [4] ; Carbone, Marianna [1] ; van Otterlo, Willem A. L. [5] ; Lopanik, Nicole B. [6] ; Waeschenbach, Andrea [7]
Total Authors: 8
Affiliation:
[1] Consiglio Nazl Ric CNR, Ist Chim Biomol ICB, Via Campi Flegrei 34, I-80078 Pozzuoli - Italy
[2] Univ Libre Bruxelles ULB, Hop Erasme, Serv Neurochirurg, B-1070 Brussels - Belgium
[3] Univ Fed Pernambuco, Ctr Biociencias, Dept Zool, BR-50670901 Recife, PE - Brazil
[4] Fonds Natl Rech Sci FRS FNRS, B-1000 Brussels - Belgium
[5] Univ Stellenbosch, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Matieland - South Africa
[6] Georgia Inst Technol, Sch Biol Sci, Sch Earth & Atmospher Sci, Atlanta, GA 30332 - USA
[7] Nat Hist Museum, Life Sci, Cromwell Rd, London SW7 5BD - England
Total Affiliations: 7
Document type: Review article
Source: MARINE DRUGS; v. 18, n. 4 APR 2020.
Web of Science Citations: 0
Abstract

Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its similar to 6000 described species. The current review is designed to highlight how bryozoans use sophisticated chemical defenses against their numerous predators and competitors, and which can be harbored for medicinal uses. This review collates all currently available chemoecological data about bryozoans and lists potential applications/benefits for human health. The core of the current review relates to the potential of bryozoan metabolites in human diseases with particular attention to viral, brain, and parasitic diseases. It additionally weighs the pros and cons of total syntheses of some bryozoan metabolites versus the synthesis of non-natural analogues, and explores the hopes put into the development of biotechnological approaches to provide sustainable amounts of bryozoan metabolites without harming the natural environment. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants