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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

H-1-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats

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Author(s):
Viana, Lais Rosa [1] ; Lopes-Aguiar, Leisa [1] ; Rosolen, Rafaela Rossi [1] ; dos Santos, Rogerio Willians [1] ; Cintra Gomes-Marcondes, Maria Cristina [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Biol Inst, Dept Struct & Funct Biol, Lab Nutr & Canc, Campinas 13083862 - Brazil
Total Affiliations: 1
Document type: Journal article
Source: METABOLITES; v. 10, n. 4 APR 2020.
Web of Science Citations: 0
Abstract

Sarcopenia among the older population has been growing over the last few years. In addition, the incidence of cancers increases with age and, consequently, the development of cachexia related cancer. Therefore, the elucidation of the metabolic derangements of sarcopenia and cachexia are important to improve the survival and life quality of cancer patients. We performed the H-1-NMR based serum metabolomics in adult (A) and ageing (S) Walker 256 tumour-bearing rats in different stages of tumour evolution, namely intermediated (Wi) and advanced (Wa). Among 52 serum metabolites that were identified, 21 were significantly increased in S and 14 and 19 decreased in the Wi and Wa groups, respectively. The most impacted pathways by this metabolic alteration were related by amino acid biosynthesis and metabolism, with an upregulation in S group and downregulation in Wi and Wa groups. Taken together, our results suggest that the increase in metabolic profile in ageing rats is associated with the higher muscle protein degradation that releases several metabolites, especially amino acids into the serum. On the other hand, we hypothesise that the majority of metabolites released by muscle catabolism are used by tumours to sustain rapid cell proliferation and tumorigenesis. (AU)

FAPESP's process: 15/21890-0 - Effect of leucine, ketogenic and combined diets in tumor growth, cachectic state and metabolomic systemic profile, muscle and tumor in rats with cancer cachexia (Walker 256 model)
Grantee:Laís Rosa Viana
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/06955-0 - Metabolomic and proteomic profile and cell proliferation and apoptosis in Walker tumour-bearing rats under pregnancy hormones and leucine-rich diet
Grantee:Laís Rosa Viana
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/02739-4 - Nutrition and cancer: study of molecular, proteomic and metabolomic aspects of experimental model of cachexia
Grantee:Maria Cristina Cintra Gomes Marcondes
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/13334-7 - Nutrition and cancer: metabolomic, and proteomic profile of muscle, placental, fetal, and tumor cell signaling pathways in Walker-256 tumour-bearing pregnant rats submitted to leucine nutritional supplementation
Grantee:Maria Cristina Cintra Gomes Marcondes
Support type: Regular Research Grants
FAPESP's process: 19/20558-2 - Nutrition and Câncer. Molecular, Proteomic and Metabolomic aspects in experimental model of cachexia.
Grantee:Leisa Lopes Aguiar
Support type: Scholarships in Brazil - Post-Doctorate