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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphism of asymmetric catalysts based on amphiphilic lipopeptides in solution

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Author(s):
Pelin, Juliane N. B. D. [1, 2] ; Edwards-Gayle, Charlotte J. C. [2] ; Aguilar, Andrea M. [3] ; Kaur, Amanpreet [2] ; Hamley, Ian W. [2] ; Alves, Wendel A. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks - England
[3] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SOFT MATTER; v. 16, n. 19, p. 4615-4624, MAY 21 2020.
Web of Science Citations: 2
Abstract

The self-assembly of model {[}P]RWG lipopeptides (P: l-proline, R: l-arginine, W: l-tryptophan, G: l-glycine), containing one or two aliphatic octadecyl (C-18) chains in water and cyclohexanone/water solutions was examined. The self-assembly of mixtures of these RWG and PRWG lipopeptides was also investigated. These materials presented a similar critical aggregation concentration of similar to 4.0 x 10(-4) wt% and were characterized by unordered secondary structures with some beta-sheet content. TEM and cryo-TEM revealed the presence of mainly nanotape structures with micelles observed for systems rich in PRWG(C18H37). Analysis of detailed SAXS form factor measurements revealed the presence of bilayers 3-4 nm thick while the PRWG(C18H37) micelles have a core radius of approximately 3 nm, and a shell thickness of 2 nm. For the cyclohexanone/water systems polymorphs containing cluster aggregates (with radius of 0.25 nm to 0.50 nm) and some elongated structures (with radius of 5.7 nm to 26.1 nm) were seen. Longer structures were formed with the increase of the proline-containing lipopeptide content. The catalytic activity of these peptides was assessed using a model nitro-aldol reaction. The concentration of water in the reaction system influenced the conversion, higher content promoted better efficiency for the water systems, but the opposite was observed for the cyclohexanone/water samples. (AU)

FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/20446-9 - Study of auto-organization in solution of hierarchical structures of peptide in presence of metallic nanoparticles
Grantee:Juliane Nogueira Batista Dias Pelin
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/12535-0 - Self-organization of hierarchical structures of peptide in solution in presence of metallic nanoparticles
Grantee:Juliane Nogueira Batista Dias Pelin
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 17/02317-2 - Interfaces in materials: electronic, magnetic, structural and transport properties
Grantee:Adalberto Fazzio
Support Opportunities: Research Projects - Thematic Grants