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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical effects of epidurally administered dexmedetomidine with or without lidocaine in sheep

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Author(s):
Mattos-Junior, Ewaldo [1] ; Flaherty, Derek [2] ; Nishimura, Lilian Toshiko [1] ; Carregaro, Adriano Bonfim [3] ; de Carvalho, Leonardo Lamarca [1]
Total Authors: 5
Affiliation:
[1] Univ Franca, Vet Sci Undergrad Program, Franca, SP - Brazil
[2] Southern Counties Vet Specialists LLP, Ringwood - England
[3] Univ Sao Paulo, Dept Zootech Sci, Pirassununga - Brazil
Total Affiliations: 3
Document type: Journal article
Source: VETERINARY RECORD; v. 186, n. 16 MAY 16 2020.
Web of Science Citations: 0
Abstract

Background The aims of this study were evaluate cardiopulmonary, sedative and antinociceptive effects of dexmedetomidine-lidocaine combination via lumbosacral epidural injection in sheep. Methods Six Santa Ines breed sheep, 16 +/- 6 months old and weighing 42.2 +/- 5.7 kg were used. Sheep were subjected to epidural anaesthesia with three treatments: L, lidocaine (1.2 mg/kg), D, dexmedetomidine (2.5 mu g/kg) or DL, dexmedetomidine plus lidocaine (2.5 mu g/kg + 1.2 mg/kg). Drugs were injected via pre-placed lumbosacral epidural catheters. Cardiopulmonary, arterial blood gases, electrolytes, degree of sedation and antinociceptive aspects were measured before drug administration (T0) and then at 15, 30, 60 and 120 min after drug injection (T15-T120) in all treatments and at T0 to T240 in DL. Results There were significantly increases in PaCO2 at times T60 and T120 in D, and at T30-T120 in DL, compared to baseline. The antinociceptive effects were observed up to 240 min in DL and 60 min in L, and were more intense in DL. Treatment D provided analgesia only in the perineal region, and only at T15. Conclusion The combination of DEX with lidocaine produced similar cardiopulmonary changes compared with either drug alone, but with greater and more prolonged antinociceptive effects. (AU)

FAPESP's process: 12/21497-8 - Cardiorespiratory, sedatives and antinociceptives effects of lidocaine, dexmedetomidine and dexmedetomidine / lidocaine via epidural approuch in sheep
Grantee:Ewaldo de Mattos Junior
Support Opportunities: Regular Research Grants