Antibacterial application of natural and carboxymethylated cashew gum-based silver nanoparticles produced by microwave-assisted synthesis

Author(s):Show less -

Araruna, Felipe Bastos ^{[1, 2]} ; de Oliveira, Taiane Maria ^[1] ; Quelemes, Patrick Veras ^[1] ; de Araujo Nobre, Alyne Rodrigues ^[1] ; Placido, Alexandra ^[3] ; Vasconcelos, Andreanne Gomes ^[4] ; Monteiro de Paula, Regina Celia ^[5] ; Mafud, Ana Carolina ^[6] ; de Almeida, Miguel Peixoto ^[7] ; Delerue-Matos, Cristina ^[3] ; Mascarenhas, Yvonne Primerano ^[6] ; Eaton, Peter ^[8] ; de Souza de Almeida Leite, Jose Roberto ^{[1, 4]} ; da Silva, Durcilene Alves ^[1]

Affiliation

^[1] Univ Fed Piaui, BIOTEC, Nucleo Pesquisa Biodiversidade & Biotecnol, UFPI, Campus Minist Reis Velloso, Ave Sao Sebastiao, BR-64202020 Parnaiba, PI - Brazil

^[2] Univ Fed Maranhao, UFMA, Programa Posgrad Biotecnol Rede Renorbio, Sao Luis, Maranhao - Brazil

^[3] Inst Politecn Porto, Inst Super Engn Porto, REQUIMTE LAQV, Porto - Portugal

^[4] Univ Brasilia, Fac Med, UnB, Area Morfol, Campus Darcy Ribeiro, Brasilia, DF - Brazil

^[5] Univ Fed Ceara, Lab Polimeros, LabPol, UFC, Fortaleza, Ceara - Brazil

^[6] Univ Sao Paulo, Inst Fis Sao Carlos, USP, IFSC, Sao Carlos, SP - Brazil

^[7] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, LAQV REQUIMTE, P-4169007 Porto - Portugal

^[8] Univ Lisbon, Fac Med, Inst Med Mol, Lisbon - Portugal

• Document type: Journal article
• Source: Carbohydrate Polymers; v. 241, AUG 1 2020.
• Web of Science Citations: 2

Abstract

This study presents a green synthesis route to silver nanoparticles (AgNPs) stabilized with cashew gum (CG) or carboxymethylated cashew gum (CCG) using microwave-assisted synthesis and evaluates their antibacterial activity. The antimicrobial activity was measured by determining the minimum inhibitory concentration (MIC) with Staphylococcus aureus and Escherichia coli. In both cases of the presence of CG and CCG, it was found that higher pH lead to more efficient conversion of silver nitrate to AgNPs with well dispersed, spherical and stable particles as well as low crystallinity. CCG-capped AgNPs were slightly smaller (137.0 and 96.3 nm) than those coated with non-modified gum (144.7 and 100.9 nm). The samples presented promising antibacterial activity, especially on Gram-negative bacteria, resulting in significant membrane damage on treated bacteria in comparison to the untreated control, observed by atomic force microscopy. Thus, a quick and efficient synthesis route was applied to produce CGAgNPs and CCGAgNPs with antimicrobial potential. (AU)

• FAPESP's process: 14/02282-6 - Structure-activity relationship studies about of Pilocarpus microphyllus (Rutaceae) alkaloid derivatives against Schistosoma mansoni
• Grantee: Ana Carolina Mafud
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/18023-5 - Preclinical studies with epiisopiloturine and epiisopilosine and their effect against other helminths
• Grantee: Ana Carolina Mafud
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor