| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo - Brazil
[2] Stefani, Helio A., Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo, Brazil.Soares-Paulino, Antonio Augusto, Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2020, n. 25 JUN 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Herein, we describe the synthesis of acyl azides and acyl urea glycals, a new class of C-2 branched glycoconjugates, employing Pd-catalyzed carbonylative coupling. A new strategy was developed to obtain acyl azides by carbonylative coupling between 2-iodo-glycals and NaN(3)catalyzed by Pd(dba)(2)/Xantphos and carbon monoxide as a carbonyl source. Acyl azide glycals were used as synthetic intermediates in obtaining new acyl urea glycals via carbonylative coupling catalyzed by Pd(OAc)(2)and 1,10-Phen. Different glycal substrates, including disaccharide-type, were studied, and various acyl azides and acyl ureas were prepared. Reaction yields were moderate to high (31-99 %) and reaction time varying from short to long (0.5-20 h). (AU) | |
| FAPESP's process: | 14/50316-7 - Dimensions US-Biota São Paulo: Chemically mediated multi-trophic interaction diversity across tropical gradients |
| Grantee: | Massuo Jorge Kato |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 18/10108-7 - Itramolecular Cycloaddition [2+2] Reactions Employing D-Glucal |
| Grantee: | Antonio Augusto Soares Paulino |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/24821-4 - Carbonylative Coupling and Intramolecular Cycloaddition [2 + 2] Reactions Employing D-Glucal |
| Grantee: | Helio Alexandre Stefani |
| Support Opportunities: | Regular Research Grants |