Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse

Author(s)

Marcus Vinicius Barbosa de Paula ^[1] ; Marcos Antônio de Farias Lira Júnior ^[2] ; Vivian Costa e Silva Crocco Monteiro ^[3] ; Ricardo Peres Souto ^[4] ; César Eduardo Fernandes ^[5] ; Emerson de Oliveira ^[6]

Affiliation

^[1] Faculdade de Medicina do ABC. Departamento de Ginecologia e Obstetrícia - Brasil

^[2] Faculdade de Medicina do ABC. Departamento de Ginecologia e Obstetrícia - Brasil

^[3] Faculdade de Medicina do ABC. Departamento de Ginecologia e Obstetrícia - Brasil

^[4] Faculdade de Medicina do ABC. Departamento de Morfologia e Psicologia - Brasil

^[5] Faculdade de Medicina do ABC. Departamento de Ginecologia e Obstetrícia - Brasil

^[6] Faculdade de medicina do ABC. Departamento de Ginecologia e Obstetrícia - Brasil

• Document type: Journal article
• Source: Revista da Associação Médica Brasileira; v. 66, n. 5, p. 680-686, 2020-07-03.

Abstract

SUMMARY OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients’ quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP. METHODS This is a cohort study with postmenopausal women who were divided into groups by POP stage: POP stages 0 and I (control group) and POP stages III and IV (case group). Subsequently, analyses of genetic polymorphisms of FBLN5 were performed using the Restriction Fragment Length Polymorphism (RFLP) technique. RESULTS A total of 292 women were included in the study. Pregnancy, parity and vaginal delivery in the patients, as well as in data described in the literature, were related to the occurrence of POP in the univariate analysis. However, after binary logistic regression, home birth and age remained independent risk factors for POP. We found no association between the FBLN5 polymorphism and the occurrence of POP (p = 0.371). CONCLUSION There was no association between the FBLN5 polymorphism and the occurrence of POP in Brazilian women. (AU)

• FAPESP's process: 14/01107-6 - Analysis of polymorphisms of genes responsible for the biosynthesis and metabolism of collagen as risk factors for development of genital prolapse
• Grantee: Emerson de Oliveira
• Support Opportunities: Regular Research Grants