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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Risk factors associated with drug therapy among elderly people with Alzheimer’s disease: a cross-sectional study

Full text
Author(s):
Marcela Forgerini [1] ; Maria Teresa Herdeiro [2] ; José Carlos Fernandes Galduróz [3] ; Patrícia de Carvalho Mastroianni [4]
Total Authors: 4
Affiliation:
[1] Universidade Estadual Paulista. School of Pharmaceutical Sciences. Department of Drugs and Medicines - Brasil
[2] Universidade de Aveiro. Institute of Biomedicine. Department of Medical Sciences - Portugal
[3] Universidade Federal de São Paulo. Department of Psychobiology - Brasil
[4] Universidade Estadual Paulista. Department of Drugs and Medicines - Brasil
Total Affiliations: 4
Document type: Journal article
Source: São Paulo Medical Journal; v. 138, n. 3, p. 216-218, 2020-06-22.
Abstract

ABSTRACT BACKGROUND: Improving knowledge and establishing strategies and policies for better patient safety are worldwide priorities. OBJECTIVE: To evaluate drug safety among elderly people with Alzheimer’s disease (AD). DESIGN AND SETTING: Cross-sectional study among elderly people within the National AD Assistance Protocol (PCDTDA/MS) who were living in the municipality of Araraquara, Brazil, in 2017. METHODS: Through interviews conducted with relatives/caregivers of elderly people with diagnoses of AD, the following variables were evaluated: comorbidities, drug therapy used, use of potentially inappropriate medications for the elderly (PIMs), presence of potentially inappropriate interactions (PIIs) and medication regimen complexity index. Factors associated with AD severity were also evaluated. Multivariate and simple logistic regressions were applied. RESULTS: 143 elderly people enrolled in PCDTDA/MS were analyzed. The majority were women (67.1%); assisted only through the public healthcare system (75.5%); polymedicated (57.4%); using at least one PIM (63.6%); presenting at least one PII (63.6%); and under drug therapy of low to medium complexity (92.2%). No semi-annual monitoring of the effectiveness of PCDTDA/MS drugs was identified. The proportion using AD drug therapy at daily doses differing from those recommended by the World Health Organization was 75.6%. However, these doses were not associated with drug risk. CONCLUSION: The data from this study raise the hypothesis that use of polypharmacy might show a correlation with severity of AD. The drug safety risk may be associated with comorbidities of the metabolic syndrome, anxiety and off-label use of PIMs, such as risperidone and quetiapine, and benzodiazepines (i.e. clonazepam and flunitrazepam). (AU)

FAPESP's process: 13/12681-2 - Evaluation of the prophylactic use of omeprazole in patients admitted to the State Hospital of Américo Brasiliense
Grantee:Patricia de Carvalho Mastroianni
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07501-9 - Genetic determinants of gastrointestinal bleeding associated with the use of ASA as an antiplalet agent: a case-control study
Grantee:Marcela Forgerini
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)