| Full text | |
| Author(s): Show less - |
Steenwyk, Jacob L.
[1]
;
Lind, Abigail L.
[2, 3]
;
Ries, Laure N. A.
[4, 5]
;
dos Reis, Thaila F.
[4, 5]
;
Silva, Lilian P.
[5]
;
Almeida, Fausto
[4]
;
Bastos, Rafael W.
[5]
;
Fraga da Silva, Thais Fernanda de Campos
[4]
;
Bonato, Vania L. D.
[4]
;
Pessoni, Andre Moreira
[4]
;
Rodrigues, Fernando
[6, 7]
;
Raja, Huzefa A.
[8]
;
Knowles, Sonja L.
[8]
;
Oberlies, Nicholas H.
[8]
;
Lagrou, Katrien
[9, 10, 11]
;
Goldman, Gustavo H.
[5]
;
Rokas, Antonis
[1, 2]
Total Authors: 17
|
| Affiliation: Show less - | [1] Vanderbilt Univ, Dept Biol Sci, 465 21st Ave South, Nashville, TN 37235 - USA
[2] Vanderbilt Univ, Dept Biomed Informat, Sch Med, 1211 Med Ctr Dr, Nashville, TN 37232 - USA
[3] Gladstone Inst Data Sci & Biotechnol, San Francisco, CA 94158 - USA
[4] Univ Sao Paulo FMRP USP, Dept Bioquim & Imunol, Vila Monte Alegre, Fac Med Ribeirao Preto, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Crencias Farmaceut, Ave Caf S-N, BR-14040903 Ribeirao Preto - Brazil
[6] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, P-4715495 Braga - Portugal
[7] ICVS 3Bs PT Govt Associate Lab, P-4715495 Braga - Portugal
[8] Univ N Carolina, Dept Chem & Biochem, 1400 Spring Garden St, Greensboro, NC 27412 - USA
[9] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, B-3000 Leuven - Belgium
[10] Univ Hosp Leuven, Dept Lab Med, B-3000 Leuven - Belgium
[11] Univ Hosp Leuven, Natl Reference Ctr Mycosis, B-3000 Leuven - Belgium
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | Current Biology; v. 30, n. 13, p. 2495+, JUL 6 2020. |
| Web of Science Citations: | 3 |
| Abstract | |
Interspecific hybridization substantially alters genotypes and phenotypes and can give rise to new lineages. Hybrid isolates that differ from their parental species in infection-relevant traits have been observed in several human-pathogenic yeasts and plant-pathogenic filamentous fungi but have yet to be found in human-pathogenic filamentous fungi. We discovered 6 clinical isolates from patients with aspergillosis originally identified as Aspergillus nidulans (section Nidulantes) that are actually allodiploid hybrids formed by the fusion of Aspergillus spinulosporus with an unknown close relative of Aspergillus quadrilineatus, both in section Nidulantes. Evolutionary genomic analyses revealed that these isolates belong to Aspergillus latus, an allodiploid hybrid species. Characterization of diverse infection-relevant traits further showed that A. latus hybrid isolates are genomically and phenotypically heterogeneous but also differ from A. nidulans, A. spinulosporus, and A. quadrilineatus. These results suggest that allodiploid hybridization contributes to the genomic and phenotypic diversity of filamentous fungal pathogens of humans. (AU) | |
| FAPESP's process: | 17/14159-2 - The role of lactose and acetate metabolism in Aspergillus fumigatus virulence |
| Grantee: | Laure Nicolas Annick Ries |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/03322-7 - Role of galectin-3 in the Cryptococcus neoformans infection |
| Grantee: | Fausto Bruno dos Reis Almeida |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence |
| Grantee: | Gustavo Henrique Goldman |
| Support Opportunities: | Research Projects - Thematic Grants |