Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anandamide in the anterior hypothalamus diminishes defensive responses elicited in mice threatened by Epicrates cenchria constrictor serpents

Full text
Author(s):
dos Anjos-Garcia, Tayllon [1, 2, 3] ; Coimbra, Norberto Cysne [1, 4, 2, 3]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Sao Paulo - Brazil
[2] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, NAP USP Neurobiol Emot Res Ctr NuPNE, Sao Paulo - Brazil
[3] Univ Sao Paulo FMRP USP, Ribeirao Preto Sch Med, Ophidiarium LNN FMRP USP INeC, Sao Paulo - Brazil
[4] Behav Neurosci Inst INeC, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ACTA NEUROBIOLOGIAE EXPERIMENTALIS; v. 80, n. 2, p. 179-191, 2020.
Web of Science Citations: 0
Abstract

The purpose of this study was to investigate whether the panicolytic-like effect of different doses of anandamide microinjected into the anterior hypothalamus (AH) follows the same pattern of a bell-shaped dose-response curve observed with the same dose treatment in dorsomedial and ventromedial hypothalamus. We investigated this assumption by administering the cannabinoid and vanilloid receptor agonist anandamide into the anterior hypothalamus of mice and exposing them to the real threatening situation by using our experimental model based on confrontations between rodents and wild snakes. Our findings showed a gradual decay of response, with a significant attenuation of the panic attack-like responses with anandamide at the highest dose but no effect was found after anandamide at the lowest or intermediate doses. An immunohistochemical procedure showed a lower degree of TRPV, receptor and moderate to higher degree of Cb, receptors in anterior hypothalamus. In conclusion, the pattern of dose-response curve of anandamide microinjected in the AH does not seem to be the same classical pattern compared with other hypothalamic nuclei. (AU)

FAPESP's process: 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 17/22647-7 - Study of glutamatergic pathways from the medial amygdala on ventromedial hypothalamus endocannabinoid signalling during the defensive behaviour elicited by mice threatened by venomous snakes
Grantee:Tayllon dos Anjos Garcia
Support Opportunities: Scholarships in Brazil - Post-Doctoral