| Full text | |
| Author(s): |
Alberca, Ricardo Wesley
[1, 2]
;
Pereira, Natalli Zanete
[1, 2]
;
Oliveira, Luanda Mara Da Silva
[1, 2]
;
Gozzi-Silva, Sarah Cristina
[3]
;
Sato, Maria Notomi
[3]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN IMMUNOLOGY; v. 11, JUL 7 2020. |
| Web of Science Citations: | 3 |
| Abstract | |
Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-induced morbidity, it is unclear how pregnancy interferes with maternal response to some viral pathogens. In this context, the novel coronavirus (SARS-CoV-2) can induce the coronavirus diseases-2019 (COVID-19) in pregnant women. The potential risk of vertical transmission is unclear, babies born from COVID-19-positive mothers seems to have no serious clinical symptoms, the possible mechanisms are discussed, which highlights that checking the children's outcome and more research is warranted. In this review, we investigate the reports concerning viral infections and COVID-19 during pregnancy, to establish a correlation and possible implications of COVID-19 during pregnancy and neonatal's health. (AU) | |
| FAPESP's process: | 19/22448-0 - Analysis of natural killer memory cells and the antiviral response of CD8 + T cells in SARS-CoV-2 infection |
| Grantee: | Sarah Cristina Gozzi e Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice |
| Grantee: | Ricardo Wesley Alberca Custódio |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/07976-0 - Obtaining, characterization and loading of autologous virus by aDC1 dendritic cells for immunotherapy anti-HIV |
| Grantee: | Luanda Mara da Silva Oliveira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |