| Full text | |
| Author(s): |
Pedrazzoli, Mario
[1]
;
Mazzotti, Diego Robles
[2]
;
Ribeiro, Amanda Oliveira
[1]
;
Mendes, Juliana Viana
[1]
;
Bittencourt, Lia Rita Azeredo
[3]
;
Tufik, Sergio
[3]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil
[2] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[3] Fed Univ Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PLoS One; v. 15, n. 7 JUL 9 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Glutamate is the most excitatory neurotransmitter in the central nervous system and it is involved in the initiation and maintaining of waking and rapid-eye-movement (REM) sleep. Homer proteins act in the trafficking and/or clustering of metabotropic glutamate receptors, and polymorphisms in theHOMER1gene have been associated with phenotypes related to glutamate signaling dysregulation. In this study, we report the association of a single nucleotide polymorphism (SNP) in theHOMER1gene (rs3822568) with specific aspects of sleep in a sample of the Brazilian population. To accomplish this, 1,042 individuals were subjected to a full-night polysomnography, and a subset of 983 subjects had rs3822568 genotyping data available. When compared with the A allele carriers, GG genotyped individuals showed higher sleep latency, lower sleep efficiency, reduced number of arousals per hour, lower apnea-hypopnea index (AHI) and lower theta spectral power. In summary, the present findings suggest that the rs3822568 polymorphism in theHOMER1gene is associated with sleep EEG profiles and might have an impact on sleep quality and sleep structure, with potential to explain inter-individual variation in sleep homeostasis. (AU) | |
| FAPESP's process: | 11/05804-5 - Phenotypic characterization of circadian rhythms in different genotype individuals for clock gene polymorphisms in different regions in Brazil: an emphasis on the effect of the gene PER3 and latitude |
| Grantee: | Mario Pedrazzoli Neto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 98/14303-3 - Center for Sleep Studies |
| Grantee: | Sergio Tufik |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |