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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The reasons to include the serology of human T-lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in the clinical follow-up of patients with viral hepatitis B and C in Brazil

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Author(s):
Campos, Karoline Rodrigues [1] ; Alves, Fabiana Aparecida [1] ; Lemos, Marcilio Figueiredo [2] ; Moreira, Regina Celia [2] ; Nascimento Marcusso, Rosa Maria [3] ; Caterino-de-Araujo, Adele [1]
Total Authors: 6
Affiliation:
[1] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz, Lab Pesquisa HTLV, Ctr Imunol, Sao Paulo, SP - Brazil
[2] Secretaria Estado Saude Sao Paulo, Coordenadoria Controle Doencas, Inst Adolfo Lutz, Lab Hepatites Virais, Ctr Virol, Sao Paulo, SP - Brazil
[3] Inst Infectol Emilio Ribas IIER, Serv Neurol Clin, Ambulatorio HTLV, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 14, n. 5 MAY 2020.
Web of Science Citations: 1
Abstract

Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology This study aimed to add information concerning the influence of human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) infections in hepatitis B and C, since in Brazil, these human retroviruses are endemic but neglected. Serum samples from 1,910 patients with hepatitis B and 1,315 with hepatitis C from Sao Paulo, southeast Brazil, that were previously tested and grouped for HIV and HTLV-1/-2 coinfections were analyzed for hepatitis B virus (HBV) and hepatitis C virus (HCV) loads measurements and subsequent clearance using data from laboratory records. Key results Briefly, the lowest HBV viral load (VL) was detected in HBV/HTLV-2 coinfected patients, regardless of whether they were infected with HIV (all comparisons p<0.05). In contrast, higher HCV VL was detected in HCV/HIV, HCV/HIV/HTLV-1/-2 coinfected patients (all p<0.05), and the lowest HCV VL was detected in HCV/HTLV-2 coinfected patients. Curiously, 61.1% of the patients with HBV/HTLV-2 coinfection had an undetectable HBV VL at the beginning of the study versus 21.4% in the patients with HBV/HTLV-1 coinfection. Although the percentages of undetectable HCV loads in HCV/HTLV-1 and HCV/HTLV-2 coinfected patients were quite similar, during follow-up, more HCV clearance was detected in patients with HCV/HTLV-2 coinfection {[}OR 2.65; 95% IC (1.17-5.99)]. Major conclusions HTLV-2 positively impacts HBV and HCV viral loads and HCV clearance, while HIV and/or HTLV-1 negatively impacts HCV viral load. Thus, the search for HTLV-1/-2 in viral hepatitis B and C infected patients has virological prognostic value, which is a strong reason to suggest including HTLV serology in the follow-up of patients. (AU)

FAPESP's process: 16/03654-0 - Host and virus genetic markers that influenced the course of the HIV-1, HIV-1/HTLV-1 and HIV-1/HTLV-2 coinfections
Grantee:Adele Caterino de Araújo
Support Opportunities: Regular Research Grants