| Full text | |
| Author(s): |
Ivani Credidio Trombetta
[1]
;
José Roberto DeMoura
;
Cleber Rene Alves
[3]
;
Renato Carbonari-Brito
[4]
;
Felipe Xerez Cepeda
[5]
;
José Ribeiro Lemos Jr
[6]
Total Authors: 6
|
| Affiliation: | [1] Universidade Nove de Julho - Brasil
[3] Universidade Nove de Julho - Brasil
[4] Universidade Nove de Julho - Brasil
[5] Universidade Nove de Julho - Brasil
[6] Polícia Militar do Estado de São Paulo. Escola de Educação Física - Brasil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; v. 115, n. 2, p. 263-269, 2020-08-28. |
| Abstract | |
Abstract Cardiovascular disease (CVD) is currently the leading cause of death in Brazil and worldwide. In 2016, CVD accounted for more than 17 million deaths, representing 31% of all deaths globally. Molecular and genetic mechanisms may be involved in vascular protection and should be considered in new therapeutic approaches. In this sense, recent studies have reported that brain-derived neurotrophic factor (BDNF) is reduced in individuals predisposed to develop CVD, and that aerobic physical training increases the amounts of circulating BDNF. BDNF is a neurotrophin found at high concentrations in the hippocampus and cerebral cortex and is considered a key molecule for the maintenance of synaptic plasticity and survival of neuronal cells. In addition to neuronal plasticity, BDNF is also important in vascular function, promoting angiogenesis through the regulation of reactive oxygen species (ROS). However, a variant of the BDNF gene in humans, the Val66Met polymorphism (substitution of the amino acid valine for a methionine at position 66 of the codon), occurring in 20-30% of the Caucasian population, may affect plasma BDNF concentrations and its activity in all peripheral tissues containing tyrosine kinase B receptors (TrkB), such as the endothelium. Thus, we will present a discussion about the role of serum BDNF levels in cardiovascular protection, Val66Met genetic variant in vascular reactivity and the effect of physical exercise. (AU) | |
| FAPESP's process: | 15/03274-0 - Diet and exercise improves metabolic, inflammatory changes and sympathovagal balance in patients with metabolic syndrome and obstructive sleep apnea |
| Grantee: | Felipe Xerez Cepêda Fonseca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/16831-7 - Metabolic/inflammatory markers and sympatho-vagal balance in patients with metabolic syndrome and obstructive sleep apnea: effect of hypocaloric diet and exercise training |
| Grantee: | Felipe Xerez Cepêda Fonseca |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |