Evaluation of diclofenac sodium incorporation in alginate membranes as potential drug release system

Author(s)

Pacheco, Murilo Santos ^[1] ; Silva, Thais Belarmino da ^[1] ; Tomoda, Bruno Thorihara ^[1] ; Moraes, Mariana Agostini de ^[1]

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Dept Chem Engn, BR-09913030 Diadema, SP - Brazil

• Document type: Journal article
• Source: MATERIALIA; v. 12, AUG 2020.
• Web of Science Citations: 0

Abstract

In this study, we proposed the use of the biopolymer alginate to produce membranes with diclofenac sodium incorporated as model-drug aiming at wound dressing application with drug delivery. The membranes were prepared by casting and the drug was incorporated directly into alginate solution, being retained within the membrane. Morphological, chemical, mechanical and barrier properties were evaluated, as well as the release kinetics in vitro using simulated exudate fluid at 37 degrees C. Results show that the membranes are malleable in the glycerol presence and more resistant to water after crosslinking. The incorporation of diclofenac sodium did not affect barrier properties, but influenced the mechanical properties, increasing the total thickness (from 0.108 to 0.209 mm) and reducing tensile strength (from 40.85 to 21.76 MPa). Drug release evaluation shows that anomalous transport is the major rate-controlling mechanism, where the swelling or erosion of the alginate matrix is the major responsible for the diclofenac sodium release, with a small contribution of Fickian diffusion mechanism. The results show the potential of application of the alginate membranes for wound dressings with drug delivery for enhancing healing process. (AU)

• FAPESP's process: 16/17555-3 - MEMBRANES OF NATURAL POLYMERS WITH ACTIVE COMPOUNDS FOR APPLICATION AS HIGH PERFORMANCE WOUND DRESSINGS
• Grantee: Mariana Agostini de Moraes
• Support Opportunities: Regular Research Grants