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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Theoretical and Experimental Analysis of Protoporphyrin IX Photodegradation Using Multi-Wavelength Light Sources

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Author(s):
Sanchez, Victor [1, 2] ; Garcia, Marlon Rodrigues [2] ; Requena, Michelle Barreto [2] ; Romano, Renan Arnon [2] ; de Boni, Leonardo [2] ; Guimaraes, Francisco E. G. [2] ; Pratavieira, Sebastiao [2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Gleb Wataghin Phys Inst, Campinas, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Photochemistry and Photobiology; v. 96, n. 6 AUG 2020.
Web of Science Citations: 0
Abstract

Photodynamic procedures have been used in many applications, ranging from cancer treatment to microorganism inactivation. Photodynamic reactions start with the activation of a photosensitizing molecule with light, leading to the production of cytotoxic molecules that promote cell death. However, establishing the correct light and photosensitizer dosimetry for a broadband light source remains challenging. In this study, we proposed a theoretical mathematical model for the photodegradation of protoporphyrin IX (PpIX), when irradiated by multi-wavelength light sources. The theoretical model predicts the experimental photobleaching (temporal change in PpIX concentration) of PpIX for different light sources. We showed that photobleaching occurs independently of the light source wavelengths but instead depends only on the number of absorbed photons. The model presented here can be used as an important mathematical approach to better understand current photodynamic therapy protocols and help achieve optimization of the doses delivered. (AU)

FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants